NO/redox disequilibrium in the failing heart and cardiovascular system

Joshua M. Hare, Jonathan S. Stamler

Research output: Contribution to journalReview articlepeer-review

295 Scopus citations


There is growing evidence that the altered production and/or spatiotemporal distribution of reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the failing heart and vascular tree, which contribute to the abnormal cardiac and vascular phenotypes that characterize the failing cardiovascular system. These derangements at the integrated system level can be interpreted at the cellular and molecular levels in terms of adverse effects on signaling elements in the heart, vasculature, and blood that subserve cardiac and vascular homeostasis.

Original languageEnglish (US)
Pages (from-to)509-517
Number of pages9
JournalJournal of Clinical Investigation
Issue number3
StatePublished - Mar 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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