Nontuberculous mycobacterial disease mortality in the United States, 1999-2010: A population-based comparative study

Mehdi Mirsaeidi, Roberto F. Machado, Joe G N Garcia, Dean E. Schraufnagel

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background: Environmental nontuberculous mycobacteria (NTM) are ubiquitous organisms with which humans commonly interact. The epidemiologic characteristics of NTM diseases including mortality rate and its associated factors remain largely unknown. In this study, we explored the geographical area of exposure and mortality and comorbid conditions of affected persons to determine environment, host, and host-pathogen interactive factors. Methods: We analyzed mortality related to nontuberculous mycobacterial infections from 1999 through 2010 by examining multiple-cause-of-death data from the National Center for Health Statistics. Among those who died with these diseases, we analyzed age-adjusted mortality rates, trends, associations with demographic variables, and comorbid conditions and correlated this information with similar data for tuberculosis-related mortality during the same time. Measurements and Mean Results: From 1999 through 2010, nontuberculous mycobacterial disease was reported as an immediate cause of death in 2,990 people in the United States with a combined overall mean age-adjusted mortality rate of 0.1 per 100,000 person-years. A significant increase in the number of NTM related deaths was seen from 1999 through 2010 (R2 = 0.72, p

Original languageEnglish (US)
Article numbere91879
JournalPLoS One
Volume9
Issue number3
DOIs
StatePublished - Mar 14 2014
Externally publishedYes

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mycobacterial diseases
Nontuberculous Mycobacteria
Mortality
Mycobacterium
Population
Pathogens
death
Cause of Death
Health
Statistics
National Center for Health Statistics (U.S.)
tuberculosis
Tuberculosis
demographic statistics
Demography
pathogens
organisms
Infection

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Nontuberculous mycobacterial disease mortality in the United States, 1999-2010 : A population-based comparative study. / Mirsaeidi, Mehdi; Machado, Roberto F.; Garcia, Joe G N; Schraufnagel, Dean E.

In: PLoS One, Vol. 9, No. 3, e91879, 14.03.2014.

Research output: Contribution to journalArticle

Mirsaeidi, Mehdi ; Machado, Roberto F. ; Garcia, Joe G N ; Schraufnagel, Dean E. / Nontuberculous mycobacterial disease mortality in the United States, 1999-2010 : A population-based comparative study. In: PLoS One. 2014 ; Vol. 9, No. 3.
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