TY - JOUR
T1 - Nontuberculous mycobacteria in Middle East
T2 - Current situation and future challenges
AU - Velayati, Ali Akbar
AU - Rahideh, Sanaz
AU - Derakhshani Nezhad, Zahra
AU - Farnia, Parissa
AU - Mirsaeidi, Mehdi
N1 - Funding Information:
This study was supported by the Mycobacteriology Research Center of Masih Daneshvari Hospital . The authors would like to send their appreciation to Dr. Marybeth Allen for her great editorial comments. Mehdi Mirsaeidi MD is supported by NIH grant 5 T32 HL 82547-7 . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Nontuberculous mycobacteria (NTM) are a diverse group of bacterial species that are distributed in the environment. Many of these environmental bacteria can cause disease in humans. The identification of NTM in environmental sources is important for both clinical and epidemiological purposes. In this study, the distribution of NTM species from environmental and clinical samples in the Middle East was reviewed. In order to provide an overview of NTM, as well as recent epidemiological trends, all studies addressing NTM in the Middle East from 1984 to 2014 were reviewed.A total of 96 articles were found, in which 1751 NTM strains were isolated and 1084 of which were obtained from clinical samples, 619 from environmental samples and 48 were cited by case reports.Mycobacterium fortuitum was the most common rapid growing mycobacteria (RGM) isolated from both clinical (269 out of 447 RGM; 60.1%) and environmental (135 out of 289 RGM; 46.7%) samples. Mycobacterium avium complex (MAC) was the most common slow growing mycobacteria (SGM) isolated from clinical samples (140 out of 637 SGM; 21.9%). An increasing trend in NTM isolation from the Middle East was noted over the last 5. years. This review demonstrates the increasing concern regarding NTM disease in the Middle East, emphasizing the need for regional collaboration and coordination in order to respond appropriately.
AB - Nontuberculous mycobacteria (NTM) are a diverse group of bacterial species that are distributed in the environment. Many of these environmental bacteria can cause disease in humans. The identification of NTM in environmental sources is important for both clinical and epidemiological purposes. In this study, the distribution of NTM species from environmental and clinical samples in the Middle East was reviewed. In order to provide an overview of NTM, as well as recent epidemiological trends, all studies addressing NTM in the Middle East from 1984 to 2014 were reviewed.A total of 96 articles were found, in which 1751 NTM strains were isolated and 1084 of which were obtained from clinical samples, 619 from environmental samples and 48 were cited by case reports.Mycobacterium fortuitum was the most common rapid growing mycobacteria (RGM) isolated from both clinical (269 out of 447 RGM; 60.1%) and environmental (135 out of 289 RGM; 46.7%) samples. Mycobacterium avium complex (MAC) was the most common slow growing mycobacteria (SGM) isolated from clinical samples (140 out of 637 SGM; 21.9%). An increasing trend in NTM isolation from the Middle East was noted over the last 5. years. This review demonstrates the increasing concern regarding NTM disease in the Middle East, emphasizing the need for regional collaboration and coordination in order to respond appropriately.
KW - Clinical samples
KW - Environmental samples
KW - Middle East
KW - Nontuberculous mycobacteria (NTM)
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U2 - 10.1016/j.ijmyco.2014.12.005
DO - 10.1016/j.ijmyco.2014.12.005
M3 - Review article
C2 - 26655192
AN - SCOPUS:84924001201
VL - 4
SP - 7
EP - 17
JO - International Journal of Mycobacteriology
JF - International Journal of Mycobacteriology
SN - 2212-5531
IS - 1
ER -