Nontuberculous mycobacteria among patients who are suspected for multidrug-resistant tuberculosis - Need for earlier identification of nontuberculosis mycobacteria

Payam Tabarsi, Parvaneh Baghaei, Parisa Farnia, Nahal Mansouri, Ehsan Chitsaz, Fatemeh Sheikholeslam, Majid Marjani, Nima Rouhani, Mehdi Mirsaeidi, Narges Alipanah, Majid Amiri, Mohammad R. Masjedi, Davood Mansouri

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

BACKGROUND: In this study, we intended to find the prevalence of nontuberculosis mycobacteria (NTM) among patients who are referred as suspected multidrug-resistant tuberculosis (MDR-TB) cases to the only referral center in Iran. METHODS: All patients referred to our center in 2002-2006 as MDR-TB with histories of treatment with standard and CAT II World Health Organization regimens were included in the study. Sputum smear and culture for acid-fast bacilli were performed for all patients 3 times. Sputum polymerase chain reaction was also performed for all patients. Mycobacterial identification was performed via polymerase chain reaction and routine identification tests for all culture-positive cases. RESULTS: Of the 105 patients in the study, 12 (11.43%) were identified to have NTM infection. The identified mycobacteria were classified in order of prevalence as Chelonae (8 cases), Simiae (2 cases), Aloei (1 case), and Farcinogen (1 case). Based on radiologic findings, most of the cases demonstrated bilateral nodularity (83.3%) and also multifocal bronchiectasis (75%). Notably, cavitary lesions were present in 41.7% of the cases. CONCLUSION: Based on the findings of this study, it is essential that such cases be identified before commencing MDR-TB treatment.

Original languageEnglish (US)
Pages (from-to)182-184
Number of pages3
JournalAmerican Journal of the Medical Sciences
Volume337
Issue number3
DOIs
StatePublished - Mar 2009
Externally publishedYes

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Nontuberculous Mycobacteria
Multidrug-Resistant Tuberculosis
Mycobacterium
Sputum
Polymerase Chain Reaction
Mycobacterium Infections
Bronchiectasis
Iran
Bacillus
Referral and Consultation
Acids
Therapeutics

Keywords

  • CAT II regimen
  • Multidrug-resistant tuberculosis
  • Nontuberculosis mycobacterium
  • PCR

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nontuberculous mycobacteria among patients who are suspected for multidrug-resistant tuberculosis - Need for earlier identification of nontuberculosis mycobacteria. / Tabarsi, Payam; Baghaei, Parvaneh; Farnia, Parisa; Mansouri, Nahal; Chitsaz, Ehsan; Sheikholeslam, Fatemeh; Marjani, Majid; Rouhani, Nima; Mirsaeidi, Mehdi; Alipanah, Narges; Amiri, Majid; Masjedi, Mohammad R.; Mansouri, Davood.

In: American Journal of the Medical Sciences, Vol. 337, No. 3, 03.2009, p. 182-184.

Research output: Contribution to journalArticle

Tabarsi, P, Baghaei, P, Farnia, P, Mansouri, N, Chitsaz, E, Sheikholeslam, F, Marjani, M, Rouhani, N, Mirsaeidi, M, Alipanah, N, Amiri, M, Masjedi, MR & Mansouri, D 2009, 'Nontuberculous mycobacteria among patients who are suspected for multidrug-resistant tuberculosis - Need for earlier identification of nontuberculosis mycobacteria', American Journal of the Medical Sciences, vol. 337, no. 3, pp. 182-184. https://doi.org/10.1097/MAJ.0b013e318185d32f
Tabarsi, Payam ; Baghaei, Parvaneh ; Farnia, Parisa ; Mansouri, Nahal ; Chitsaz, Ehsan ; Sheikholeslam, Fatemeh ; Marjani, Majid ; Rouhani, Nima ; Mirsaeidi, Mehdi ; Alipanah, Narges ; Amiri, Majid ; Masjedi, Mohammad R. ; Mansouri, Davood. / Nontuberculous mycobacteria among patients who are suspected for multidrug-resistant tuberculosis - Need for earlier identification of nontuberculosis mycobacteria. In: American Journal of the Medical Sciences. 2009 ; Vol. 337, No. 3. pp. 182-184.
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