Abstract
BACKGROUND: In this study, we intended to find the prevalence of nontuberculosis mycobacteria (NTM) among patients who are referred as suspected multidrug-resistant tuberculosis (MDR-TB) cases to the only referral center in Iran. METHODS: All patients referred to our center in 2002-2006 as MDR-TB with histories of treatment with standard and CAT II World Health Organization regimens were included in the study. Sputum smear and culture for acid-fast bacilli were performed for all patients 3 times. Sputum polymerase chain reaction was also performed for all patients. Mycobacterial identification was performed via polymerase chain reaction and routine identification tests for all culture-positive cases. RESULTS: Of the 105 patients in the study, 12 (11.43%) were identified to have NTM infection. The identified mycobacteria were classified in order of prevalence as Chelonae (8 cases), Simiae (2 cases), Aloei (1 case), and Farcinogen (1 case). Based on radiologic findings, most of the cases demonstrated bilateral nodularity (83.3%) and also multifocal bronchiectasis (75%). Notably, cavitary lesions were present in 41.7% of the cases. CONCLUSION: Based on the findings of this study, it is essential that such cases be identified before commencing MDR-TB treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 182-184 |
| Number of pages | 3 |
| Journal | American Journal of the Medical Sciences |
| Volume | 337 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2009 |
| Externally published | Yes |
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Keywords
- CAT II regimen
- Multidrug-resistant tuberculosis
- Nontuberculosis mycobacterium
- PCR
ASJC Scopus subject areas
- Medicine(all)
Cite this
Nontuberculous mycobacteria among patients who are suspected for multidrug-resistant tuberculosis - Need for earlier identification of nontuberculosis mycobacteria. / Tabarsi, Payam; Baghaei, Parvaneh; Farnia, Parisa; Mansouri, Nahal; Chitsaz, Ehsan; Sheikholeslam, Fatemeh; Marjani, Majid; Rouhani, Nima; Mirsaeidi, Mehdi; Alipanah, Narges; Amiri, Majid; Masjedi, Mohammad R.; Mansouri, Davood.
In: American Journal of the Medical Sciences, Vol. 337, No. 3, 03.2009, p. 182-184.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nontuberculous mycobacteria among patients who are suspected for multidrug-resistant tuberculosis - Need for earlier identification of nontuberculosis mycobacteria
AU - Tabarsi, Payam
AU - Baghaei, Parvaneh
AU - Farnia, Parisa
AU - Mansouri, Nahal
AU - Chitsaz, Ehsan
AU - Sheikholeslam, Fatemeh
AU - Marjani, Majid
AU - Rouhani, Nima
AU - Mirsaeidi, Mehdi
AU - Alipanah, Narges
AU - Amiri, Majid
AU - Masjedi, Mohammad R.
AU - Mansouri, Davood
PY - 2009/3
Y1 - 2009/3
N2 - BACKGROUND: In this study, we intended to find the prevalence of nontuberculosis mycobacteria (NTM) among patients who are referred as suspected multidrug-resistant tuberculosis (MDR-TB) cases to the only referral center in Iran. METHODS: All patients referred to our center in 2002-2006 as MDR-TB with histories of treatment with standard and CAT II World Health Organization regimens were included in the study. Sputum smear and culture for acid-fast bacilli were performed for all patients 3 times. Sputum polymerase chain reaction was also performed for all patients. Mycobacterial identification was performed via polymerase chain reaction and routine identification tests for all culture-positive cases. RESULTS: Of the 105 patients in the study, 12 (11.43%) were identified to have NTM infection. The identified mycobacteria were classified in order of prevalence as Chelonae (8 cases), Simiae (2 cases), Aloei (1 case), and Farcinogen (1 case). Based on radiologic findings, most of the cases demonstrated bilateral nodularity (83.3%) and also multifocal bronchiectasis (75%). Notably, cavitary lesions were present in 41.7% of the cases. CONCLUSION: Based on the findings of this study, it is essential that such cases be identified before commencing MDR-TB treatment.
AB - BACKGROUND: In this study, we intended to find the prevalence of nontuberculosis mycobacteria (NTM) among patients who are referred as suspected multidrug-resistant tuberculosis (MDR-TB) cases to the only referral center in Iran. METHODS: All patients referred to our center in 2002-2006 as MDR-TB with histories of treatment with standard and CAT II World Health Organization regimens were included in the study. Sputum smear and culture for acid-fast bacilli were performed for all patients 3 times. Sputum polymerase chain reaction was also performed for all patients. Mycobacterial identification was performed via polymerase chain reaction and routine identification tests for all culture-positive cases. RESULTS: Of the 105 patients in the study, 12 (11.43%) were identified to have NTM infection. The identified mycobacteria were classified in order of prevalence as Chelonae (8 cases), Simiae (2 cases), Aloei (1 case), and Farcinogen (1 case). Based on radiologic findings, most of the cases demonstrated bilateral nodularity (83.3%) and also multifocal bronchiectasis (75%). Notably, cavitary lesions were present in 41.7% of the cases. CONCLUSION: Based on the findings of this study, it is essential that such cases be identified before commencing MDR-TB treatment.
KW - CAT II regimen
KW - Multidrug-resistant tuberculosis
KW - Nontuberculosis mycobacterium
KW - PCR
UR - http://www.scopus.com/inward/record.url?scp=63249093056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63249093056&partnerID=8YFLogxK
U2 - 10.1097/MAJ.0b013e318185d32f
DO - 10.1097/MAJ.0b013e318185d32f
M3 - Article
C2 - 19301453
AN - SCOPUS:63249093056
VL - 337
SP - 182
EP - 184
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 3
ER -