Nonthrombogenic and cell nonadhesive substrates based on polyethylene oxide modified surfaces

Neil P. Desai, Jeffrey A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have previously demonstrated the SPIN (surface physical interpenetrating network) technique of achieving immobilization of PEO/PEG onto the surface of a biomaterial. Polyethylene terephthalate (PET), a polyurethane (pellethane), and polymethyl methacrylate (PMMA) were modified using this technique for PEO incorporation. In the present study we report further analysis of this system in terms of surface characterization, in vivo evaluation, and bacterial adherence. This work reinforces the fact that PEO 18.5k is a suitable modifier in applications that require biologically nonfouling surfaces. The SPIN technique is a simple, versatile, nonchemical method of modifying a substrate or device to acheive these properties.

Original languageEnglish
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Place of PublicationAlgonquin, IL, United States
PublisherPubl by Soc for Biomaterials
Volume14
StatePublished - Jan 1 1991
Externally publishedYes
Event17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA
Duration: May 1 1991May 5 1991

Other

Other17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
CityScottsdale, AZ, USA
Period5/1/915/5/91

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Desai, N. P., & Hubbell, J. A. (1991). Nonthrombogenic and cell nonadhesive substrates based on polyethylene oxide modified surfaces. In Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 14). Publ by Soc for Biomaterials.