Nonsyndromic cleft lip and palate: No evidence of linkage to HLA or factor 13A

Jacqueline T. Hecht, Yaping Wang, Barbara Connor, Susan H Blanton, Stephen P. Daiger

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Nonsyndromic cleft lip with or without cleft palate (CLP) is a common craniofacial anomaly, the etiology of which is not known. Population studies have shown that a large proportion of cases occur sporadically. Recently, segregation analyses applied to CLP families have demonstrated that an autosomal dominant/codominant gene(s) may cause clefting in cases. Associations of autosomal dominant CLP and nonsyndromic cleft palate (CP) with HLA and F13A genes on chromosome 6p have been suggested previously. Linkage to these two areas on chromosome 6p were tested in 12 autosomal dominant families with CLP. With a LOD score of -2 or less for exclusion, no evidence of linkage was found to four chromosome 6p markers. Multipoint analysis showed no evidence of a clefting locus in this region spanning 54 cM on chromosome 6p in these CLP families.

Original languageEnglish
Pages (from-to)1230-1233
Number of pages4
JournalAmerican Journal of Human Genetics
Volume52
Issue number6
StatePublished - Jun 1 1993
Externally publishedYes

Fingerprint

Cleft Palate
Chromosomes
Dominant Genes
Cleft Lip
Genetic Markers
Orofacial Cleft 1
Population
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Nonsyndromic cleft lip and palate : No evidence of linkage to HLA or factor 13A. / Hecht, Jacqueline T.; Wang, Yaping; Connor, Barbara; Blanton, Susan H; Daiger, Stephen P.

In: American Journal of Human Genetics, Vol. 52, No. 6, 01.06.1993, p. 1230-1233.

Research output: Contribution to journalArticle

Hecht, JT, Wang, Y, Connor, B, Blanton, SH & Daiger, SP 1993, 'Nonsyndromic cleft lip and palate: No evidence of linkage to HLA or factor 13A', American Journal of Human Genetics, vol. 52, no. 6, pp. 1230-1233.
Hecht, Jacqueline T. ; Wang, Yaping ; Connor, Barbara ; Blanton, Susan H ; Daiger, Stephen P. / Nonsyndromic cleft lip and palate : No evidence of linkage to HLA or factor 13A. In: American Journal of Human Genetics. 1993 ; Vol. 52, No. 6. pp. 1230-1233.
@article{796f1cb1c7ad4f8382631d15be944777,
title = "Nonsyndromic cleft lip and palate: No evidence of linkage to HLA or factor 13A",
abstract = "Nonsyndromic cleft lip with or without cleft palate (CLP) is a common craniofacial anomaly, the etiology of which is not known. Population studies have shown that a large proportion of cases occur sporadically. Recently, segregation analyses applied to CLP families have demonstrated that an autosomal dominant/codominant gene(s) may cause clefting in cases. Associations of autosomal dominant CLP and nonsyndromic cleft palate (CP) with HLA and F13A genes on chromosome 6p have been suggested previously. Linkage to these two areas on chromosome 6p were tested in 12 autosomal dominant families with CLP. With a LOD score of -2 or less for exclusion, no evidence of linkage was found to four chromosome 6p markers. Multipoint analysis showed no evidence of a clefting locus in this region spanning 54 cM on chromosome 6p in these CLP families.",
author = "Hecht, {Jacqueline T.} and Yaping Wang and Barbara Connor and Blanton, {Susan H} and Daiger, {Stephen P.}",
year = "1993",
month = "6",
day = "1",
language = "English",
volume = "52",
pages = "1230--1233",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Nonsyndromic cleft lip and palate

T2 - No evidence of linkage to HLA or factor 13A

AU - Hecht, Jacqueline T.

AU - Wang, Yaping

AU - Connor, Barbara

AU - Blanton, Susan H

AU - Daiger, Stephen P.

PY - 1993/6/1

Y1 - 1993/6/1

N2 - Nonsyndromic cleft lip with or without cleft palate (CLP) is a common craniofacial anomaly, the etiology of which is not known. Population studies have shown that a large proportion of cases occur sporadically. Recently, segregation analyses applied to CLP families have demonstrated that an autosomal dominant/codominant gene(s) may cause clefting in cases. Associations of autosomal dominant CLP and nonsyndromic cleft palate (CP) with HLA and F13A genes on chromosome 6p have been suggested previously. Linkage to these two areas on chromosome 6p were tested in 12 autosomal dominant families with CLP. With a LOD score of -2 or less for exclusion, no evidence of linkage was found to four chromosome 6p markers. Multipoint analysis showed no evidence of a clefting locus in this region spanning 54 cM on chromosome 6p in these CLP families.

AB - Nonsyndromic cleft lip with or without cleft palate (CLP) is a common craniofacial anomaly, the etiology of which is not known. Population studies have shown that a large proportion of cases occur sporadically. Recently, segregation analyses applied to CLP families have demonstrated that an autosomal dominant/codominant gene(s) may cause clefting in cases. Associations of autosomal dominant CLP and nonsyndromic cleft palate (CP) with HLA and F13A genes on chromosome 6p have been suggested previously. Linkage to these two areas on chromosome 6p were tested in 12 autosomal dominant families with CLP. With a LOD score of -2 or less for exclusion, no evidence of linkage was found to four chromosome 6p markers. Multipoint analysis showed no evidence of a clefting locus in this region spanning 54 cM on chromosome 6p in these CLP families.

UR - http://www.scopus.com/inward/record.url?scp=0027426277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027426277&partnerID=8YFLogxK

M3 - Article

C2 - 8099257

AN - SCOPUS:0027426277

VL - 52

SP - 1230

EP - 1233

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 6

ER -