TY - JOUR
T1 - Nonsteroidal anti-inflammatory drug induced thrombotic thrombocytopenic purpura
AU - Oregel, Karlos Z.
AU - Ramdial, Jeremy
AU - Glück, Stefan
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/11/14
Y1 - 2013/11/14
N2 - A 21-year-old male presented to the emergency department after a 5-day history of recurrent vomiting and decreased urine output. History revealed ingestion of ibuprofen. During the diagnostic workup, the following was identified: white blood cell count 13.4 (×10(3)/mcL), hemoglobin 11.9 (×10(6)/mcL) with an MCV of 73 fL, hematocrit 34% and platelets were 31,000/mcL, sodium of 130 mmol/L, potassium of 5.1 mmol/L, chloride of 83 mmol/L, bicarbonate of 21 mmol/L, blood urea nitrogen of 184 mg/dL and creatinine of 19.1 mg/dL. He was later diagnosed with thrombotic throm-bocytopenic purpura (TTP) based on the fact that he presented with most components of the TTP pentad (except for fever), which included altered mental status, acute kidney injury, thrombocytopenia, and evidence of red cell fragmentation and his ADAMTS13 level was found to be less than 10% prior to therapy. Te patient then received plasma exchange, oral corticosteroids, and hemodialysis, which led to a full recovery of platelet count and renal function.
AB - A 21-year-old male presented to the emergency department after a 5-day history of recurrent vomiting and decreased urine output. History revealed ingestion of ibuprofen. During the diagnostic workup, the following was identified: white blood cell count 13.4 (×10(3)/mcL), hemoglobin 11.9 (×10(6)/mcL) with an MCV of 73 fL, hematocrit 34% and platelets were 31,000/mcL, sodium of 130 mmol/L, potassium of 5.1 mmol/L, chloride of 83 mmol/L, bicarbonate of 21 mmol/L, blood urea nitrogen of 184 mg/dL and creatinine of 19.1 mg/dL. He was later diagnosed with thrombotic throm-bocytopenic purpura (TTP) based on the fact that he presented with most components of the TTP pentad (except for fever), which included altered mental status, acute kidney injury, thrombocytopenia, and evidence of red cell fragmentation and his ADAMTS13 level was found to be less than 10% prior to therapy. Te patient then received plasma exchange, oral corticosteroids, and hemodialysis, which led to a full recovery of platelet count and renal function.
KW - Drug-induced TTP
KW - Ibuprofen
KW - NSAIDs
KW - Thrombotic thrombocytopenic purpura
KW - TTP
UR - http://www.scopus.com/inward/record.url?scp=84887691168&partnerID=8YFLogxK
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U2 - 10.4137/CMBd.s12843
DO - 10.4137/CMBd.s12843
M3 - Article
AN - SCOPUS:84887691168
VL - 6
SP - 19
EP - 22
JO - Clinical Medicine Insights: Blood Disorders
JF - Clinical Medicine Insights: Blood Disorders
SN - 1179-545X
ER -