Nonselective loss of contrast sensitivity in visual system testing in early type I diabetes

Mauro A S Di Leo, Salvatore Caputo, Benedetto Falsini, Vittorio Porciatti, Angelo Minnella, Aldo V. Greco, Giovanni Ghirlanda

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - Psychophysical methods in patients with diabetes mellitus reveal deficits of central or foveal vision. Our aim was to evaluate the contrast-sensitivity thresholds in 24 insulin-dependent (type I) diabetic patients with a short disease duration and without retinopathy, taking into account metabolic control. RESEARCH DESIGN AND METHODS - The control group consisted of age-matched nondiabetic subjects. None had visual or systemic symptoms. Contrast sensitivity measured at eight different spatial frequencies to sinusoidal bar patterns of 0.6-12.2 cycles/deg can detect functional defects in the spatially sensitive retinal ganglion cells or in higher visual pathways. We performed two different temporal types of contrast-sensitivity testing, dynamic (8 Hz) and static (0 Hz). RESULTS - Significant losses with dynamic contrast-sensitivity test at all but the highest spatial frequencies (i.e., 12.2 cycles/deg) were shown, whereas there was significant attenuation of contrast sensitivity at five spatial frequencies (1.0, 1.4, 2.2, 7.1, and 9.6 cycles/deg) in the static mode. Grating losses (<2SD of control means) of contrast sensitivity were found in 33.3% (dynamic) and in 72.9% (static) of eyes of diabetic patients. HbA1c values were positively correlated at variable spatial frequencies (1.0, 1.4, and 2.2 cycles/deg for dynamic test and 0.6, 1.0, 1.4, 2.2, 4.8, and 7.1 cycles/deg for static test). CONCLUSIONS - Our results suggest an early, generally nonselective neuronal damage of visual pathways that occurs before the onset of clinically detectable retinopathy. The visual deficit may be related directly to the effects of diabetes; repetitive minor hypoglycemic insults may contribute more than a marked hyperglycemic condition to the mechanisms underlying physiological changes along the optic nerve.

Original languageEnglish
Pages (from-to)620-625
Number of pages6
JournalDiabetes Care
Volume15
Issue number5
StatePublished - May 1 1992
Externally publishedYes

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Contrast Sensitivity
Type 1 Diabetes Mellitus
Visual Pathways
Retinal Ganglion Cells
Optic Nerve
Hypoglycemic Agents
Diabetes Mellitus
Research Design
Insulin
Control Groups

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Di Leo, M. A. S., Caputo, S., Falsini, B., Porciatti, V., Minnella, A., Greco, A. V., & Ghirlanda, G. (1992). Nonselective loss of contrast sensitivity in visual system testing in early type I diabetes. Diabetes Care, 15(5), 620-625.

Nonselective loss of contrast sensitivity in visual system testing in early type I diabetes. / Di Leo, Mauro A S; Caputo, Salvatore; Falsini, Benedetto; Porciatti, Vittorio; Minnella, Angelo; Greco, Aldo V.; Ghirlanda, Giovanni.

In: Diabetes Care, Vol. 15, No. 5, 01.05.1992, p. 620-625.

Research output: Contribution to journalArticle

Di Leo, MAS, Caputo, S, Falsini, B, Porciatti, V, Minnella, A, Greco, AV & Ghirlanda, G 1992, 'Nonselective loss of contrast sensitivity in visual system testing in early type I diabetes', Diabetes Care, vol. 15, no. 5, pp. 620-625.
Di Leo MAS, Caputo S, Falsini B, Porciatti V, Minnella A, Greco AV et al. Nonselective loss of contrast sensitivity in visual system testing in early type I diabetes. Diabetes Care. 1992 May 1;15(5):620-625.
Di Leo, Mauro A S ; Caputo, Salvatore ; Falsini, Benedetto ; Porciatti, Vittorio ; Minnella, Angelo ; Greco, Aldo V. ; Ghirlanda, Giovanni. / Nonselective loss of contrast sensitivity in visual system testing in early type I diabetes. In: Diabetes Care. 1992 ; Vol. 15, No. 5. pp. 620-625.
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