Nonpathogenic simian immunodeficiency virus infections

Nichole Klatt, Guido Silvestri, Vanessa Hirsch

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The simian immunodeficiency viruses (SIVs) are a diverse group of viruses that naturally infect a wide range of African primates, including African green monkeys (AGMs) and sooty mangabey monkeys (SMs). Although natural infection is widespread in feral populations of AGMs and SMs, this infection generally does not result in immunodeficiency. However, experimental inoculation of Asian macaques results in an immunodeficiency syndrome remarkably similar to human AIDS. Thus, natural nonprogressive SIV infections appear to represent an evolutionary adaptation between these animals and their primate lentiviruses. Curiously, these animals maintain robust virus replication but have evolved strategies to avoid disease progression. Adaptations observed in these primates include phenotypic changes to CD4+ T cells, limited chronic immune activation, and altered mucosal immunity. It is probable that these animals have achieved a unique balance between T-cell renewal and proliferation and loss through activation-induced apoptosis, and virus-induced cell death. A clearer understanding of the mechanisms underlying the lack of disease progression in natural hosts for SIV infection should therefore yield insights into the pathogenesis of AIDS and may inform vaccine design.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in medicine
Volume2
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

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Simian Immunodeficiency Virus
Cercocebus atys
Virus Diseases
Viruses
Cercopithecus aethiops
Primates
Haplorhini
Disease Progression
Acquired Immunodeficiency Syndrome
Primate Lentiviruses
T-Lymphocytes
Mucosal Immunity
Animals
T-cells
Macaca
Virus Replication
Infection
Cell Death
Vaccines
Chemical activation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nonpathogenic simian immunodeficiency virus infections. / Klatt, Nichole; Silvestri, Guido; Hirsch, Vanessa.

In: Cold Spring Harbor perspectives in medicine, Vol. 2, No. 1, 01.01.2012.

Research output: Contribution to journalArticle

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