Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses

Dong Song, Robert E. Hampson, Brian S. Robinson, Ioan Opris, Vasilis Z. Marmarelis, Sam A. Deadwyler, Theodore W. Berger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper reports the first nonlinear dynamical model of human hippocampus for building memory prostheses. In this study, spike trains are recorded from the hippocampal CA3 and CA1 regions in epileptic patients performing two memory-dependent behavioral tasks. Using CA3 and CA1 spike trains as inputs and outputs respectively, second-order generalized Laguerre-Volterra models are built to capture the nonlinear dynamics underlying the spike train transformations. These models can predict the CA1 spike trains based on the CA3 spike train and thus be used as the computational basis of the hippocampal memory prosthesis.

Original languageEnglish (US)
Title of host publication2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015
PublisherIEEE Computer Society
Pages316-319
Number of pages4
ISBN (Electronic)9781467363891
DOIs
StatePublished - Jul 1 2015
Externally publishedYes
Event7th International IEEE/EMBS Conference on Neural Engineering, NER 2015 - Montpellier, France
Duration: Apr 22 2015Apr 24 2015

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
Volume2015-July
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Other

Other7th International IEEE/EMBS Conference on Neural Engineering, NER 2015
CountryFrance
CityMontpellier
Period4/22/154/24/15

ASJC Scopus subject areas

  • Artificial Intelligence
  • Mechanical Engineering

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