Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses

Dong Song; Robert E. Hampson; Brian S. Robinson; Ioan Opris; Vasilis Z. Marmarelis; Sam A. Deadwyler; Theodore W. Berger

doi:10.1109/NER.2015.7146623

Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses

Dong Song, Robert E. Hampson, Brian S. Robinson, Ioan Opris, Vasilis Z. Marmarelis, Sam A. Deadwyler, Theodore W. Berger

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

This paper reports the first nonlinear dynamical model of human hippocampus for building memory prostheses. In this study, spike trains are recorded from the hippocampal CA3 and CA1 regions in epileptic patients performing two memory-dependent behavioral tasks. Using CA3 and CA1 spike trains as inputs and outputs respectively, second-order generalized Laguerre-Volterra models are built to capture the nonlinear dynamics underlying the spike train transformations. These models can predict the CA1 spike trains based on the CA3 spike train and thus be used as the computational basis of the hippocampal memory prosthesis.

Original language	English (US)
Title of host publication	2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015
Publisher	IEEE Computer Society
Pages	316-319
Number of pages	4
ISBN (Electronic)	9781467363891
DOIs	https://doi.org/10.1109/NER.2015.7146623
State	Published - Jul 1 2015
Externally published	Yes
Event	7th International IEEE/EMBS Conference on Neural Engineering, NER 2015 - Montpellier, France Duration: Apr 22 2015 → Apr 24 2015

Publication series

Name	International IEEE/EMBS Conference on Neural Engineering, NER
Volume	2015-July
ISSN (Print)	1948-3546
ISSN (Electronic)	1948-3554

Other

Other	7th International IEEE/EMBS Conference on Neural Engineering, NER 2015
Country	France
City	Montpellier
Period	4/22/15 → 4/24/15

ASJC Scopus subject areas

Artificial Intelligence
Mechanical Engineering

Access to Document

10.1109/NER.2015.7146623

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Cite this

Song, D., Hampson, R. E., Robinson, B. S., Opris, I., Marmarelis, V. Z., Deadwyler, S. A., & Berger, T. W. (2015). Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses. In 2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015 (pp. 316-319). [7146623] (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2015-July). IEEE Computer Society. https://doi.org/10.1109/NER.2015.7146623

Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses. / Song, Dong; Hampson, Robert E.; Robinson, Brian S.; Opris, Ioan; Marmarelis, Vasilis Z.; Deadwyler, Sam A.; Berger, Theodore W.

2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015. IEEE Computer Society, 2015. p. 316-319 7146623 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2015-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Song, D, Hampson, RE, Robinson, BS, Opris, I, Marmarelis, VZ, Deadwyler, SA & Berger, TW 2015, Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses. in 2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015., 7146623, International IEEE/EMBS Conference on Neural Engineering, NER, vol. 2015-July, IEEE Computer Society, pp. 316-319, 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015, Montpellier, France, 4/22/15. https://doi.org/10.1109/NER.2015.7146623

Song D, Hampson RE, Robinson BS, Opris I, Marmarelis VZ, Deadwyler SA et al. Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses. In 2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015. IEEE Computer Society. 2015. p. 316-319. 7146623. (International IEEE/EMBS Conference on Neural Engineering, NER). https://doi.org/10.1109/NER.2015.7146623

Song, Dong ; Hampson, Robert E. ; Robinson, Brian S. ; Opris, Ioan ; Marmarelis, Vasilis Z. ; Deadwyler, Sam A. ; Berger, Theodore W. / Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses. 2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015. IEEE Computer Society, 2015. pp. 316-319 (International IEEE/EMBS Conference on Neural Engineering, NER).

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abstract = "This paper reports the first nonlinear dynamical model of human hippocampus for building memory prostheses. In this study, spike trains are recorded from the hippocampal CA3 and CA1 regions in epileptic patients performing two memory-dependent behavioral tasks. Using CA3 and CA1 spike trains as inputs and outputs respectively, second-order generalized Laguerre-Volterra models are built to capture the nonlinear dynamics underlying the spike train transformations. These models can predict the CA1 spike trains based on the CA3 spike train and thus be used as the computational basis of the hippocampal memory prosthesis.",

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