TY - GEN
T1 - Nonlinear dynamical modeling of human hippocampal CA3-CA1 functional connectivity for memory prostheses
AU - Song, Dong
AU - Hampson, Robert E.
AU - Robinson, Brian S.
AU - Opris, Ioan
AU - Marmarelis, Vasilis Z.
AU - Deadwyler, Sam A.
AU - Berger, Theodore W.
N1 - Publisher Copyright:
© 2015 IEEE.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - This paper reports the first nonlinear dynamical model of human hippocampus for building memory prostheses. In this study, spike trains are recorded from the hippocampal CA3 and CA1 regions in epileptic patients performing two memory-dependent behavioral tasks. Using CA3 and CA1 spike trains as inputs and outputs respectively, second-order generalized Laguerre-Volterra models are built to capture the nonlinear dynamics underlying the spike train transformations. These models can predict the CA1 spike trains based on the CA3 spike train and thus be used as the computational basis of the hippocampal memory prosthesis.
AB - This paper reports the first nonlinear dynamical model of human hippocampus for building memory prostheses. In this study, spike trains are recorded from the hippocampal CA3 and CA1 regions in epileptic patients performing two memory-dependent behavioral tasks. Using CA3 and CA1 spike trains as inputs and outputs respectively, second-order generalized Laguerre-Volterra models are built to capture the nonlinear dynamics underlying the spike train transformations. These models can predict the CA1 spike trains based on the CA3 spike train and thus be used as the computational basis of the hippocampal memory prosthesis.
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U2 - 10.1109/NER.2015.7146623
DO - 10.1109/NER.2015.7146623
M3 - Conference contribution
AN - SCOPUS:84940376205
T3 - International IEEE/EMBS Conference on Neural Engineering, NER
SP - 316
EP - 319
BT - 2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015
PB - IEEE Computer Society
T2 - 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015
Y2 - 22 April 2015 through 24 April 2015
ER -