Noninvasive muscle oxygenation to guide fluid resuscitation after traumatic shock

Bruce A. Crookes, Stephen M. Cohn, Elizabeth A. Burton, Jacob Nelson, Kenneth G Proctor

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background Three different protocols tested the hypothesis that hind limb muscle tissue O2 saturation (StO2), measured noninvasively with near-infrared spectroscopy (NIRS), is as reliable as invasive systemic oxygenation indices to guide fluid resuscitation. Methods In series 1, swine (n=30) were hemorrhaged, then received either no fluid, a fixed volume of colloid (15 mL/kg), or shed blood plus lactated Ringer's (LR) titrated to MAP >60 mm Hg. In series 2, swine (n=16) received a penetrating femur injury, a 47% to 55% hemorrhage to determine a median lethal dose (LD50) then shed blood plus LR titrated to MAP >60 mm Hg. In series 3, swine (n=5) received the femur injury plus LD50 hemorrhage, and were resuscitated with LR titrated to StO2 >50%. Results In series 1, StO 2 tracked mixed venous O2 saturation (SvO2), but discriminated between 3 survivor groups better than SvO2, arterial lactate, or arterial base excess. In series 2, StO2 tracked SvO2 but discriminated between 2 survivor groups better than SvO 2, arterial lactate, or arterial base excess. In series 3, animals survived to extubation when resuscitated to an StO2 target. Conclusions Noninvasive muscle StO2 determined by NIRS was more reliable than invasive oxygenation variables as an index of shock. Because muscle StO2 can be easily monitored in emergency situations, it may represent an improved method to gauge the severity of shock or the adequacy of fluid resuscitation after trauma.

Original languageEnglish
Pages (from-to)662-670
Number of pages9
JournalSurgery
Volume135
Issue number6
DOIs
StatePublished - Jun 1 2004

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Traumatic Shock
Resuscitation
Swine
Near-Infrared Spectroscopy
Lethal Dose 50
Muscles
Femur
Shock
Lactic Acid
Wounds and Injuries
Hemorrhage
Colloids
Emergencies
Extremities
Ringer's lactate

ASJC Scopus subject areas

  • Surgery

Cite this

Noninvasive muscle oxygenation to guide fluid resuscitation after traumatic shock. / Crookes, Bruce A.; Cohn, Stephen M.; Burton, Elizabeth A.; Nelson, Jacob; Proctor, Kenneth G.

In: Surgery, Vol. 135, No. 6, 01.06.2004, p. 662-670.

Research output: Contribution to journalArticle

Crookes, Bruce A. ; Cohn, Stephen M. ; Burton, Elizabeth A. ; Nelson, Jacob ; Proctor, Kenneth G. / Noninvasive muscle oxygenation to guide fluid resuscitation after traumatic shock. In: Surgery. 2004 ; Vol. 135, No. 6. pp. 662-670.
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