Nonhuman primate ocular biometry

Robert C. Augusteyn, Bianca Maceo Heilman, Arthur Ho, Jean Marie Parel

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

PURPOSE. To examine ocular growth in nonhuman primates (NHPs) from measurements on ex vivo eyes. METHODS. We obtained NHP eyes from animals that had been killed as part of other studies or because of health-related issues. Digital calipers were used to measure the horizontal, vertical, and anteroposterior globe diameters as well as corneal horizontal and vertical diameters of excised globes from 98 hamadryas baboons, 551 cynomolgus monkeys, and 112 rhesus monkeys, at ages ranging from 23 to 360 months. Isolated lens sagittal thickness and equatorial diameter were measured by shadowphotogrammetry. Wet and fixed dry weights were obtained for lenses. RESULTS. Nonhuman primate globe growth continues throughout life, slowing toward an asymptotic maximum. The final globe size scales with negative allometry to adult body size. Corneal growth ceases at around 20 months. Lens diameter increases but thickness decreases with increasing age. Nonhuman primate lens wet and dry weight accumulation is monophasic, continuing throughout life toward asymptotic maxima. The dry/wet weight ratio reaches a maximum of 0.33. CONCLUSIONS. Nonhuman primate ocular globe and lens growth differ in several respects from those in humans. Although age-related losses of lens power and accommodative amplitude are similar, lens growth and properties are different indicating care should be taken in extrapolating NHP observations to the study of human accommodation.

Original languageEnglish (US)
Pages (from-to)105-114
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Volume57
Issue number1
DOIs
StatePublished - Jan 2016

Keywords

  • Aging
  • Baboon
  • Cornea
  • Cynomolgus monkey
  • Globe
  • Lens
  • NHP
  • Nonhuman primates
  • Ocular biometry
  • Rhesus monkey

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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