Abstract
PURPOSE. To investigate the changes in the epithelium and flap after laser in situ keratomileusis (LASIK), when measured with optical coherence tomography (OCT). METHODS. Twenty-eight eyes of 14 patients (age: 39.9 ± 8.6 years) underwent LASIK. The central thickness of corneal epithelium and flap were measured with a real-time 1310 nm OCT 1 day, 1 week, and 1 month after surgery. A custom software program was used to process multiple images of each eye on each visit. RESULTS. After surgery, the corneal epithelium changed significantly (ANOVA: F(3, 81) = 12.3, P = 0.000) with not statistically significant thinning at one day (mean ± SD: 57.8 ± 5.9 μm, P = 0.26, compared with baseline: 59.9 ± 5.9 μm) and statistically significant thickening at 1 week (60.8 ± 5.8 μm, P = 0.04, compared with 1 day) and 1 month (64.6 ± 6.1 μm, P = 0.008 compared with all others). There were statistically significant changes in the corneal flap thickness (ANOVA: F(2, 54) = 4.59, P = 0.01) with thickening in the intervals between 1 day (143.3 ± 20.6 μm) and 1 week (149.7 ± 24.6 μm, P = 0.12), and between 1 week and 1 month (152.7 ± 19.3 μm, P = 0.01). There was a strong correlation (r = 0.898) between the difference of corneal thickness before and after surgery and predicted laser ablation depth. CONCLUSIONS. OCT is a useful noncontact tool for thickness measurements of the epithelium, flap, and total cornea. After LASIK, the epithelium and flap showed thickening during the study period.
| Original language | English |
|---|---|
| Pages (from-to) | 1812-1816 |
| Number of pages | 5 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 45 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
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Noncontact measurements of central corneal epithelial and flap thickness after laser in situ keratomileusis. / Wang, Jianhua; Thomas, Joseph; Cox, Ian; Rollins, Andrew.
In: Investigative Ophthalmology and Visual Science, Vol. 45, No. 6, 01.06.2004, p. 1812-1816.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Noncontact measurements of central corneal epithelial and flap thickness after laser in situ keratomileusis
AU - Wang, Jianhua
AU - Thomas, Joseph
AU - Cox, Ian
AU - Rollins, Andrew
PY - 2004/6/1
Y1 - 2004/6/1
N2 - PURPOSE. To investigate the changes in the epithelium and flap after laser in situ keratomileusis (LASIK), when measured with optical coherence tomography (OCT). METHODS. Twenty-eight eyes of 14 patients (age: 39.9 ± 8.6 years) underwent LASIK. The central thickness of corneal epithelium and flap were measured with a real-time 1310 nm OCT 1 day, 1 week, and 1 month after surgery. A custom software program was used to process multiple images of each eye on each visit. RESULTS. After surgery, the corneal epithelium changed significantly (ANOVA: F(3, 81) = 12.3, P = 0.000) with not statistically significant thinning at one day (mean ± SD: 57.8 ± 5.9 μm, P = 0.26, compared with baseline: 59.9 ± 5.9 μm) and statistically significant thickening at 1 week (60.8 ± 5.8 μm, P = 0.04, compared with 1 day) and 1 month (64.6 ± 6.1 μm, P = 0.008 compared with all others). There were statistically significant changes in the corneal flap thickness (ANOVA: F(2, 54) = 4.59, P = 0.01) with thickening in the intervals between 1 day (143.3 ± 20.6 μm) and 1 week (149.7 ± 24.6 μm, P = 0.12), and between 1 week and 1 month (152.7 ± 19.3 μm, P = 0.01). There was a strong correlation (r = 0.898) between the difference of corneal thickness before and after surgery and predicted laser ablation depth. CONCLUSIONS. OCT is a useful noncontact tool for thickness measurements of the epithelium, flap, and total cornea. After LASIK, the epithelium and flap showed thickening during the study period.
AB - PURPOSE. To investigate the changes in the epithelium and flap after laser in situ keratomileusis (LASIK), when measured with optical coherence tomography (OCT). METHODS. Twenty-eight eyes of 14 patients (age: 39.9 ± 8.6 years) underwent LASIK. The central thickness of corneal epithelium and flap were measured with a real-time 1310 nm OCT 1 day, 1 week, and 1 month after surgery. A custom software program was used to process multiple images of each eye on each visit. RESULTS. After surgery, the corneal epithelium changed significantly (ANOVA: F(3, 81) = 12.3, P = 0.000) with not statistically significant thinning at one day (mean ± SD: 57.8 ± 5.9 μm, P = 0.26, compared with baseline: 59.9 ± 5.9 μm) and statistically significant thickening at 1 week (60.8 ± 5.8 μm, P = 0.04, compared with 1 day) and 1 month (64.6 ± 6.1 μm, P = 0.008 compared with all others). There were statistically significant changes in the corneal flap thickness (ANOVA: F(2, 54) = 4.59, P = 0.01) with thickening in the intervals between 1 day (143.3 ± 20.6 μm) and 1 week (149.7 ± 24.6 μm, P = 0.12), and between 1 week and 1 month (152.7 ± 19.3 μm, P = 0.01). There was a strong correlation (r = 0.898) between the difference of corneal thickness before and after surgery and predicted laser ablation depth. CONCLUSIONS. OCT is a useful noncontact tool for thickness measurements of the epithelium, flap, and total cornea. After LASIK, the epithelium and flap showed thickening during the study period.
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U2 - 10.1167/iovs.03-1088
DO - 10.1167/iovs.03-1088
M3 - Article
C2 - 15161844
AN - SCOPUS:3042580061
VL - 45
SP - 1812
EP - 1816
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 6
ER -