Noncoding RNAs in ischemic stroke: time to translate

Harpreet Kaur, Deepaneeta Sarmah, Jackson Saraf, Kanchan Vats, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, Kunjan R. Dave, Zhumur Ghosh, Pallab Bhattacharya

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Stroke is devastating and a major cause of morbidity and mortality around globe. Current interventions for ischemic stroke include thrombolytics, clot retrieval devices and/or intravenous tissue plasminogen activators (tPA), the latter two becoming the first line of treatment. Owing to the limitations of tPA to elicit therapeutic benefits in a narrow time window, new pharmacological interventions are needed. Exploring noncoding RNAs (ncRNAs) may be a promising option for stroke treatment. ncRNAs are endogenous molecules that play key roles in the pathophysiology of many functions and diseases, including during ischemic stroke. Small ncRNAs such as microRNAs, Piwi-interacting RNAs, and long ncRNAs affect the genetic machinery at molecular levels. These small ncRNAs, along with their target genes and RNA transcripts, are involved in repair and recovery mechanisms after stroke. The potential of ncRNAs to regulate physiological processes highlights their potential therapeutic importance. Here, we enumerate the details and roles of different types of ncRNAs as biomarkers and targets for future stroke intervention.

Original languageEnglish (US)
Pages (from-to)19-36
Number of pages18
JournalAnnals of the New York Academy of Sciences
Volume1421
Issue number1
DOIs
StatePublished - Jun 2018

Keywords

  • Piwi-interacting RNA
  • ischemic stroke
  • long noncoding RNA
  • micro-RNA
  • neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Fingerprint

Dive into the research topics of 'Noncoding RNAs in ischemic stroke: time to translate'. Together they form a unique fingerprint.

Cite this