Noncoding RNAs in ischemic stroke: Time to translate

Harpreet Kaur, Deepaneeta Sarmah, Jackson Saraf, Kanchan Vats, Kiran Kalia, Anupom Borah, Dileep R Yavagal, Kunjan R Dave, Zhumur Ghosh, Pallab Bhattacharya

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Stroke is devastating and a major cause of morbidity and mortality around globe. Current interventions for ischemic stroke include thrombolytics, clot retrieval devices and/or intravenous tissue plasminogen activators (tPA), the latter two becoming the first line of treatment. Owing to the limitations of tPA to elicit therapeutic benefits in a narrow time window, new pharmacological interventions are needed. Exploring noncoding RNAs (ncRNAs) may be a promising option for stroke treatment. ncRNAs are endogenous molecules that play key roles in the pathophysiology of many functions and diseases, including during ischemic stroke. Small ncRNAs such as microRNAs, Piwi-interacting RNAs, and long ncRNAs affect the genetic machinery at molecular levels. These small ncRNAs, along with their target genes and RNA transcripts, are involved in repair and recovery mechanisms after stroke. The potential of ncRNAs to regulate physiological processes highlights their potential therapeutic importance. Here, we enumerate the details and roles of different types of ncRNAs as biomarkers and targets for future stroke intervention.

Original languageEnglish (US)
JournalAnnals of the New York Academy of Sciences
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Untranslated RNA
Stroke
Small Untranslated RNA
Tissue Plasminogen Activator
Long Noncoding RNA
Biomarkers
MicroRNAs
Physiological Phenomena
Small Interfering RNA
Machinery
Repair
Genes
RNA
Recovery
Molecules
Pharmacology
Morbidity
Equipment and Supplies
Mortality
Therapeutics

Keywords

  • Ischemic stroke
  • Long noncoding RNA
  • Micro-RNA
  • Neuroprotection
  • Piwi-interacting RNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Kaur, H., Sarmah, D., Saraf, J., Vats, K., Kalia, K., Borah, A., ... Bhattacharya, P. (Accepted/In press). Noncoding RNAs in ischemic stroke: Time to translate. Annals of the New York Academy of Sciences. https://doi.org/10.1111/nyas.13612

Noncoding RNAs in ischemic stroke : Time to translate. / Kaur, Harpreet; Sarmah, Deepaneeta; Saraf, Jackson; Vats, Kanchan; Kalia, Kiran; Borah, Anupom; Yavagal, Dileep R; Dave, Kunjan R; Ghosh, Zhumur; Bhattacharya, Pallab.

In: Annals of the New York Academy of Sciences, 01.01.2018.

Research output: Contribution to journalArticle

Kaur, Harpreet ; Sarmah, Deepaneeta ; Saraf, Jackson ; Vats, Kanchan ; Kalia, Kiran ; Borah, Anupom ; Yavagal, Dileep R ; Dave, Kunjan R ; Ghosh, Zhumur ; Bhattacharya, Pallab. / Noncoding RNAs in ischemic stroke : Time to translate. In: Annals of the New York Academy of Sciences. 2018.
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