Noncoding RNAs in ischemic stroke: Time to translate

Harpreet Kaur, Deepaneeta Sarmah, Jackson Saraf, Kanchan Vats, Kiran Kalia, Anupom Borah, Dileep R Yavagal, Kunjan R Dave, Zhumur Ghosh, Pallab Bhattacharya

Research output: Contribution to journalArticle

17 Scopus citations


Stroke is devastating and a major cause of morbidity and mortality around globe. Current interventions for ischemic stroke include thrombolytics, clot retrieval devices and/or intravenous tissue plasminogen activators (tPA), the latter two becoming the first line of treatment. Owing to the limitations of tPA to elicit therapeutic benefits in a narrow time window, new pharmacological interventions are needed. Exploring noncoding RNAs (ncRNAs) may be a promising option for stroke treatment. ncRNAs are endogenous molecules that play key roles in the pathophysiology of many functions and diseases, including during ischemic stroke. Small ncRNAs such as microRNAs, Piwi-interacting RNAs, and long ncRNAs affect the genetic machinery at molecular levels. These small ncRNAs, along with their target genes and RNA transcripts, are involved in repair and recovery mechanisms after stroke. The potential of ncRNAs to regulate physiological processes highlights their potential therapeutic importance. Here, we enumerate the details and roles of different types of ncRNAs as biomarkers and targets for future stroke intervention.

Original languageEnglish (US)
JournalAnnals of the New York Academy of Sciences
StateAccepted/In press - Jan 1 2018


  • Ischemic stroke
  • Long noncoding RNA
  • Micro-RNA
  • Neuroprotection
  • Piwi-interacting RNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Kaur, H., Sarmah, D., Saraf, J., Vats, K., Kalia, K., Borah, A., Yavagal, D. R., Dave, K. R., Ghosh, Z., & Bhattacharya, P. (Accepted/In press). Noncoding RNAs in ischemic stroke: Time to translate. Annals of the New York Academy of Sciences.