Nonavailability of Poison Antidotes

Mary Ann Howland, Richard Weisman, Diane Sauter, Lewis Goldfrank

Research output: Contribution to journalLetterpeer-review

25 Scopus citations


To the Editor: The New York City Poison Control Center was recently consulted about a suicide attempt in which the victim ingested several packets of the rodenticide Vacor (N-3-pyridylmethyl-N′-p-nitrophenylurea). The rodenticide was manufactured in the 1970s but was withdrawn from the market in June 1979, after 12 human deaths were reported. Structurally, Vacor is related to streptozocin and alloxan, and like the former, it destroys the beta cells of the pancreas. It is believed that nicotinamide (niacinamide) antagonism is responsible for toxicity.1 Rats that were given parenteral nicotinamide within three hours of an oral exposure to Vacor did not exhibit…, No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Pages (from-to)927-928
Number of pages2
JournalNew England Journal of Medicine
Issue number14
StatePublished - Apr 3 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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