Nonalbumin proteinuria in islet transplant recipients

Cristiane B. Leitão, Tatiana Froud, Pablo Cure, Thipaporn Tharavanij, Antonello Pileggi, Camillo Ricordi, Rodolfo Alejandro

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The aim of this study was to evaluate the importance of nonalbumin-predominant proteinuria on kidney function (KF) after islet transplantation (ITx). Twenty-four-hour proteinuria and albuminuria were available in 27 recipients. KF was assessed by serum creatinine and estimated glomerular filtration rate (eGFR) was calculated by Modification of Diet in Renal Disease formula. Correlations between eGFR and albuminuria (r = -0.422, p < 0.001) were higher than with proteinuria (r = -0.223, p < 0.001; p = 0.006 for comparison between correlations). Nineteen (70%) subjects had proteinuria > 300 mg/24 h during the follow-up. Subjects were divided into three groups according to urinary protein excretion patterns: no proteinuria (n = 8), nonalbumin-predominant (n = 8), and albumin-predominant (n = 11) proteinuria. Proteinuria ≥ 500 mg/24 h was observed only among patients with albumin-predominant proteinuria (64%; p = 0.002) and these patients had the lowest eGFR means post-ITx (no proteinuria: 84.2 ± 16.4 vs. nonalbumin: 69.1 ± 13.8 vs. albuminpredominant proteinuria: 65.5 ± 16.6 ml/min/1.73 m2, p = 0.044 for first vs. last group). In conclusion, high frequency of proteinuria was observed after ITx. However, it seems to be milder and have less impact on KF when albumin is not the major source of proteinuria. Prospective evaluation of proteinuria, including tubular function markers, should be performed to elucidate the mechanisms of kidney damage in this population.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalCell transplantation
Volume19
Issue number1
DOIs
StatePublished - 2010

Keywords

  • Albuminuria
  • Islet transplantation
  • Kidney function
  • Nonalbumin
  • Proteinuria
  • Type 1 diabetes

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation
  • Biomedical Engineering

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