Nichtinvasive bestimmung des intrakraniellen drucks: Mr-basierte untersuchung bei kindern mit hydrozephalus

Translated title of the contribution: Non-invasive estimation of intracranial pressure. Mr-based evaluation in children with hydrocephalus

M. Muehlmann, D. Steffinger, A. Peraud, M. Lehner, F. Heinen, Noam Alperin, B. Ertl-Wagner, I. K. Koerte

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Clinical/methodical issue: The intracranial pressure (ICP) is a crucially important parameter for diagnostic and therapeutic decision-making in patients with hydrocephalus. Standard radiological methods: So far there is no standard method to non-invasively assess the ICP. Various approaches to obtain the ICP semi-invasively or non-invasively are discussed and the clinical application of a magnetic resonance imaging (MRI)-based method to estimate ICP (MR-ICP) is demonstrated in a group of pediatric patients with hydrocephalus. Methodical innovations: Arterial inflow, venous drainage and craniospinal cerebrospinal fluid (CSF) flow were quantified using phase-contrast imaging to derive the MR-ICP. Performance: A total of 15 patients with hydrocephalus (n=9 treated with shunt placement or ventriculostomy) underwent MRI on a 3 T scanner applying retrospectively-gated cine phase contrast sequences. Of the patients six had clinical symptoms indicating increased ICP (age 2.5-14.61 years, mean 7.4 years) and nine patients had no clinical signs of elevated ICP (age 2.1-15.9 years; mean 9.8 years; all treated with shunt or ventriculostomy). Median MR-ICP in symptomatic patients was 24.5 mmHg (25th percentile 20.4 mmHg; 75th percentile 44.6 mmHg). Median MR-ICP in patients without acute signs of increased ICP was 9.8 mmHg (25th percentile 8.6 mmHg; 75th percentile 11.4 mmHg). Group differences were significant (p <0.001; Mann-Whitney U-test). Achievements: The MR-ICP technique is a promising non-invasive tool for estimating ICP. Practical recommendations: Further studies in larger patient cohorts are warranted to investigate its application in children with hydrocephalus.

Original languageGerman
Pages (from-to)827-832
Number of pages6
JournalRadiologe
Volume52
Issue number9
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Fingerprint

Intracranial Pressure
Hydrocephalus
Ventriculostomy
Magnetic Resonance Imaging
Intracranial Hypertension
Nonparametric Statistics
Decision Making
Pediatrics

Keywords

  • Diagnostic imaging
  • Hydrocephalus
  • Intracranial pressure
  • Non-invasive method
  • Phase contrast imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Nichtinvasive bestimmung des intrakraniellen drucks : Mr-basierte untersuchung bei kindern mit hydrozephalus. / Muehlmann, M.; Steffinger, D.; Peraud, A.; Lehner, M.; Heinen, F.; Alperin, Noam; Ertl-Wagner, B.; Koerte, I. K.

In: Radiologe, Vol. 52, No. 9, 01.09.2012, p. 827-832.

Research output: Contribution to journalArticle

Muehlmann, M, Steffinger, D, Peraud, A, Lehner, M, Heinen, F, Alperin, N, Ertl-Wagner, B & Koerte, IK 2012, 'Nichtinvasive bestimmung des intrakraniellen drucks: Mr-basierte untersuchung bei kindern mit hydrozephalus', Radiologe, vol. 52, no. 9, pp. 827-832. https://doi.org/10.1007/s00117-012-2326-z
Muehlmann, M. ; Steffinger, D. ; Peraud, A. ; Lehner, M. ; Heinen, F. ; Alperin, Noam ; Ertl-Wagner, B. ; Koerte, I. K. / Nichtinvasive bestimmung des intrakraniellen drucks : Mr-basierte untersuchung bei kindern mit hydrozephalus. In: Radiologe. 2012 ; Vol. 52, No. 9. pp. 827-832.
@article{95872ba0d04c40a3b80b2ac8b9b21159,
title = "Nichtinvasive bestimmung des intrakraniellen drucks: Mr-basierte untersuchung bei kindern mit hydrozephalus",
abstract = "Clinical/methodical issue: The intracranial pressure (ICP) is a crucially important parameter for diagnostic and therapeutic decision-making in patients with hydrocephalus. Standard radiological methods: So far there is no standard method to non-invasively assess the ICP. Various approaches to obtain the ICP semi-invasively or non-invasively are discussed and the clinical application of a magnetic resonance imaging (MRI)-based method to estimate ICP (MR-ICP) is demonstrated in a group of pediatric patients with hydrocephalus. Methodical innovations: Arterial inflow, venous drainage and craniospinal cerebrospinal fluid (CSF) flow were quantified using phase-contrast imaging to derive the MR-ICP. Performance: A total of 15 patients with hydrocephalus (n=9 treated with shunt placement or ventriculostomy) underwent MRI on a 3 T scanner applying retrospectively-gated cine phase contrast sequences. Of the patients six had clinical symptoms indicating increased ICP (age 2.5-14.61 years, mean 7.4 years) and nine patients had no clinical signs of elevated ICP (age 2.1-15.9 years; mean 9.8 years; all treated with shunt or ventriculostomy). Median MR-ICP in symptomatic patients was 24.5 mmHg (25th percentile 20.4 mmHg; 75th percentile 44.6 mmHg). Median MR-ICP in patients without acute signs of increased ICP was 9.8 mmHg (25th percentile 8.6 mmHg; 75th percentile 11.4 mmHg). Group differences were significant (p <0.001; Mann-Whitney U-test). Achievements: The MR-ICP technique is a promising non-invasive tool for estimating ICP. Practical recommendations: Further studies in larger patient cohorts are warranted to investigate its application in children with hydrocephalus.",
keywords = "Diagnostic imaging, Hydrocephalus, Intracranial pressure, Non-invasive method, Phase contrast imaging",
author = "M. Muehlmann and D. Steffinger and A. Peraud and M. Lehner and F. Heinen and Noam Alperin and B. Ertl-Wagner and Koerte, {I. K.}",
year = "2012",
month = "9",
day = "1",
doi = "10.1007/s00117-012-2326-z",
language = "German",
volume = "52",
pages = "827--832",
journal = "Der Radiologe",
issn = "0033-832X",
publisher = "Springer Verlag",
number = "9",

}

TY - JOUR

T1 - Nichtinvasive bestimmung des intrakraniellen drucks

T2 - Mr-basierte untersuchung bei kindern mit hydrozephalus

AU - Muehlmann, M.

AU - Steffinger, D.

AU - Peraud, A.

AU - Lehner, M.

AU - Heinen, F.

AU - Alperin, Noam

AU - Ertl-Wagner, B.

AU - Koerte, I. K.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Clinical/methodical issue: The intracranial pressure (ICP) is a crucially important parameter for diagnostic and therapeutic decision-making in patients with hydrocephalus. Standard radiological methods: So far there is no standard method to non-invasively assess the ICP. Various approaches to obtain the ICP semi-invasively or non-invasively are discussed and the clinical application of a magnetic resonance imaging (MRI)-based method to estimate ICP (MR-ICP) is demonstrated in a group of pediatric patients with hydrocephalus. Methodical innovations: Arterial inflow, venous drainage and craniospinal cerebrospinal fluid (CSF) flow were quantified using phase-contrast imaging to derive the MR-ICP. Performance: A total of 15 patients with hydrocephalus (n=9 treated with shunt placement or ventriculostomy) underwent MRI on a 3 T scanner applying retrospectively-gated cine phase contrast sequences. Of the patients six had clinical symptoms indicating increased ICP (age 2.5-14.61 years, mean 7.4 years) and nine patients had no clinical signs of elevated ICP (age 2.1-15.9 years; mean 9.8 years; all treated with shunt or ventriculostomy). Median MR-ICP in symptomatic patients was 24.5 mmHg (25th percentile 20.4 mmHg; 75th percentile 44.6 mmHg). Median MR-ICP in patients without acute signs of increased ICP was 9.8 mmHg (25th percentile 8.6 mmHg; 75th percentile 11.4 mmHg). Group differences were significant (p <0.001; Mann-Whitney U-test). Achievements: The MR-ICP technique is a promising non-invasive tool for estimating ICP. Practical recommendations: Further studies in larger patient cohorts are warranted to investigate its application in children with hydrocephalus.

AB - Clinical/methodical issue: The intracranial pressure (ICP) is a crucially important parameter for diagnostic and therapeutic decision-making in patients with hydrocephalus. Standard radiological methods: So far there is no standard method to non-invasively assess the ICP. Various approaches to obtain the ICP semi-invasively or non-invasively are discussed and the clinical application of a magnetic resonance imaging (MRI)-based method to estimate ICP (MR-ICP) is demonstrated in a group of pediatric patients with hydrocephalus. Methodical innovations: Arterial inflow, venous drainage and craniospinal cerebrospinal fluid (CSF) flow were quantified using phase-contrast imaging to derive the MR-ICP. Performance: A total of 15 patients with hydrocephalus (n=9 treated with shunt placement or ventriculostomy) underwent MRI on a 3 T scanner applying retrospectively-gated cine phase contrast sequences. Of the patients six had clinical symptoms indicating increased ICP (age 2.5-14.61 years, mean 7.4 years) and nine patients had no clinical signs of elevated ICP (age 2.1-15.9 years; mean 9.8 years; all treated with shunt or ventriculostomy). Median MR-ICP in symptomatic patients was 24.5 mmHg (25th percentile 20.4 mmHg; 75th percentile 44.6 mmHg). Median MR-ICP in patients without acute signs of increased ICP was 9.8 mmHg (25th percentile 8.6 mmHg; 75th percentile 11.4 mmHg). Group differences were significant (p <0.001; Mann-Whitney U-test). Achievements: The MR-ICP technique is a promising non-invasive tool for estimating ICP. Practical recommendations: Further studies in larger patient cohorts are warranted to investigate its application in children with hydrocephalus.

KW - Diagnostic imaging

KW - Hydrocephalus

KW - Intracranial pressure

KW - Non-invasive method

KW - Phase contrast imaging

UR - http://www.scopus.com/inward/record.url?scp=84866902757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866902757&partnerID=8YFLogxK

U2 - 10.1007/s00117-012-2326-z

DO - 10.1007/s00117-012-2326-z

M3 - Article

C2 - 22903585

AN - SCOPUS:84866902757

VL - 52

SP - 827

EP - 832

JO - Der Radiologe

JF - Der Radiologe

SN - 0033-832X

IS - 9

ER -