Nichtinvasive bestimmung des intrakraniellen drucks: Mr-basierte untersuchung bei kindern mit hydrozephalus

Translated title of the contribution: Non-invasive estimation of intracranial pressure. Mr-based evaluation in children with hydrocephalus

M. Muehlmann, D. Steffinger, A. Peraud, M. Lehner, F. Heinen, N. Alperin, B. Ertl-Wagner, I. K. Koerte

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Clinical/methodical issue: The intracranial pressure (ICP) is a crucially important parameter for diagnostic and therapeutic decision-making in patients with hydrocephalus. Standard radiological methods: So far there is no standard method to non-invasively assess the ICP. Various approaches to obtain the ICP semi-invasively or non-invasively are discussed and the clinical application of a magnetic resonance imaging (MRI)-based method to estimate ICP (MR-ICP) is demonstrated in a group of pediatric patients with hydrocephalus. Methodical innovations: Arterial inflow, venous drainage and craniospinal cerebrospinal fluid (CSF) flow were quantified using phase-contrast imaging to derive the MR-ICP. Performance: A total of 15 patients with hydrocephalus (n=9 treated with shunt placement or ventriculostomy) underwent MRI on a 3 T scanner applying retrospectively-gated cine phase contrast sequences. Of the patients six had clinical symptoms indicating increased ICP (age 2.5-14.61 years, mean 7.4 years) and nine patients had no clinical signs of elevated ICP (age 2.1-15.9 years; mean 9.8 years; all treated with shunt or ventriculostomy). Median MR-ICP in symptomatic patients was 24.5 mmHg (25th percentile 20.4 mmHg; 75th percentile 44.6 mmHg). Median MR-ICP in patients without acute signs of increased ICP was 9.8 mmHg (25th percentile 8.6 mmHg; 75th percentile 11.4 mmHg). Group differences were significant (p <0.001; Mann-Whitney U-test). Achievements: The MR-ICP technique is a promising non-invasive tool for estimating ICP. Practical recommendations: Further studies in larger patient cohorts are warranted to investigate its application in children with hydrocephalus.

Translated title of the contributionNon-invasive estimation of intracranial pressure. Mr-based evaluation in children with hydrocephalus
Original languageGerman
Pages (from-to)827-832
Number of pages6
Issue number9
StatePublished - Sep 2012


  • Diagnostic imaging
  • Hydrocephalus
  • Intracranial pressure
  • Non-invasive method
  • Phase contrast imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


Dive into the research topics of 'Non-invasive estimation of intracranial pressure. Mr-based evaluation in children with hydrocephalus: Mr-basierte untersuchung bei kindern mit hydrozephalus'. Together they form a unique fingerprint.

Cite this