Non-injected illicit drug use and infectious disease risk of donor tissue: a single institution retrospective review

Mark D. Barton, Amir Qureshi, Anita Vijapura, H. Thomas Temple

Research output: Contribution to journalArticle

Abstract

This study assessed the relationship of non-injected illicit drug use and infectious disease seropositivity for human immunodeficiency virus (HIV-1), hepatitis B virus (HBV), hepatitis C virus (HCV), and Syphilis. In a retrospective review of 986 donor charts recovered from 2009 to 2011 at a single tissue bank, the absence of reported non-injected illicit drug use corresponded with seropositivity in 6.61 %, of recovered donors while reported illicit drug use in the medical and social history corresponded with seropositivity in 11.25 %, representing a 70 % increased risk. There was no significant difference noted for overall seropositivity rates between types on noninjected illicit drugs, although donors that used cocaine had a higher incidence of HIV, while marijuana use was associated with a higher rate of HBV, HCV, and syphilis positivity. Toxicology screening results were not an accurate predictor of seropositivity (PPV = 3.77 %; NPV = 91.56 %). Further, the degree of relationship between the donor and the next of kin had no bearing on the veracity of actual drug use when comparing the response of the medical-social history and the toxicology screen.

Original languageEnglish (US)
Pages (from-to)623-629
Number of pages7
JournalCell and Tissue Banking
Volume16
Issue number4
DOIs
StatePublished - Dec 1 2015

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Keywords

  • Illicit drug use
  • Seropositivity
  • Tissue banking

ASJC Scopus subject areas

  • Transplantation
  • Biomaterials
  • Biomedical Engineering
  • Cell Biology

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