Non-coding RNA transcripts: Sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease

Research output: Contribution to journalReview article

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Abstract

Non-protein-coding RNAs (ncRNAs) play critical roles on many levels of cellular information processing and pervasive expression of ncRNAs in the nervous system could help explain brain complexity. NcRNAs are enriched in the central nervous system and are associated with specific neuroanatomical regions. Additionally, several recent publications have revealed an important role for deregulation of ncRNAs in various human neuropathologies, such as Alzheimer's disease, Parkinson's disease and Fragile X mental retardation. Herein, we summarize reports on functional ncRNA molecules involved in cellular stress response, particularly related to Alzheimer's disease. We conclude that ncRNAs have a prominent role in maintaining precise physiological levels of gene products directly implicated in Alzheimer's disease pathology.

Original languageEnglish (US)
Pages (from-to)81-88
Number of pages8
JournalNeuroscience Letters
Volume466
Issue number2
DOIs
StatePublished - Dec 4 2009
Externally publishedYes

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Keywords

  • Alzheimer's disease
  • Neuronal stress
  • Non-coding RNA
  • Synaptic plasticity
  • Transcriptome

ASJC Scopus subject areas

  • Neuroscience(all)

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