Non-antioxidant molecular functions of α-tocopherol (vitamin E)

Angelo Azzi; Roberta Ricciarelli; Jean Marc Zingg

doi:10.1016/S0014-5793(02)02706-0

Non-antioxidant molecular functions of α-tocopherol (vitamin E)

Angelo Azzi, Roberta Ricciarelli, Jean Marc Zingg

Research output: Contribution to journal › Short survey › peer-review

271 Scopus citations

Abstract

α-Tocopherol (the major vitamin E component) regulates key cellular events by mechanisms unrelated with its antioxidant function. Inhibition of protein kinase C (PKC) activity and vascular smooth muscle cell growth by α-tocopherol was first described by our group. Later, α-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages. α-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression.

Original language	English (US)
Pages (from-to)	8-10
Number of pages	3
Journal	FEBS letters
Volume	519
Issue number	1-3
DOIs	https://doi.org/10.1016/S0014-5793(02)02706-0
State	Published - May 22 2002
Externally published	Yes

Keywords

α-Tocopherol
Cell proliferation
Gene expression
Non-antioxidant mechanism
Oxygen burst
Platelet aggregation
Protein kinase C

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(02)02706-0

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title = "Non-antioxidant molecular functions of α-tocopherol (vitamin E)",

abstract = "α-Tocopherol (the major vitamin E component) regulates key cellular events by mechanisms unrelated with its antioxidant function. Inhibition of protein kinase C (PKC) activity and vascular smooth muscle cell growth by α-tocopherol was first described by our group. Later, α-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages. α-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression.",

keywords = "α-Tocopherol, Cell proliferation, Gene expression, Non-antioxidant mechanism, Oxygen burst, Platelet aggregation, Protein kinase C",

author = "Angelo Azzi and Roberta Ricciarelli and Zingg, {Jean Marc}",

note = "Funding Information: The studies reported here have been supported by the Swiss National Science Foundation, by the Foundation for Nutrition in Switzerland and by Bayer Vital.",

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doi = "10.1016/S0014-5793(02)02706-0",

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T1 - Non-antioxidant molecular functions of α-tocopherol (vitamin E)

AU - Azzi, Angelo

AU - Ricciarelli, Roberta

AU - Zingg, Jean Marc

N1 - Funding Information: The studies reported here have been supported by the Swiss National Science Foundation, by the Foundation for Nutrition in Switzerland and by Bayer Vital.

PY - 2002/5/22

Y1 - 2002/5/22

N2 - α-Tocopherol (the major vitamin E component) regulates key cellular events by mechanisms unrelated with its antioxidant function. Inhibition of protein kinase C (PKC) activity and vascular smooth muscle cell growth by α-tocopherol was first described by our group. Later, α-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages. α-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression.

AB - α-Tocopherol (the major vitamin E component) regulates key cellular events by mechanisms unrelated with its antioxidant function. Inhibition of protein kinase C (PKC) activity and vascular smooth muscle cell growth by α-tocopherol was first described by our group. Later, α-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages. α-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression.

KW - α-Tocopherol

KW - Cell proliferation

KW - Gene expression

KW - Non-antioxidant mechanism

KW - Oxygen burst

KW - Platelet aggregation

KW - Protein kinase C

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U2 - 10.1016/S0014-5793(02)02706-0

DO - 10.1016/S0014-5793(02)02706-0

M3 - Short survey

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AN - SCOPUS:0037157196

VL - 519

SP - 8

EP - 10

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1-3

ER -

Non-antioxidant molecular functions of α-tocopherol (vitamin E)

Abstract

Keywords

ASJC Scopus subject areas

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