Noggin is a mesenchymally derived stimulator of hair-follicle induction

Vladimir A. Botchkarev, Natalia V. Botchkareva, Wera Roth, Motonobu Nakamura, Ling Hong Chen, Wiebke Herzog, Gerd Lindner, Jill A. McMahon, Christoph Peters, Roland Lauster, Andrew P. McMahon, Ralf Paus

Research output: Contribution to journalArticle

295 Citations (Scopus)

Abstract

The induction of developmental structures derived from the ectoderm, such as the neural tube or tooth, occurs through neutralization of the inhibitory activity of members of the bone-morphogenetic protein (BMP) family by BMP antagonists. Here we show that, during hair-follicle development, the neural inducer and BMP-neutralizing protein Noggin is expressed in the follicular mesenchyme, that noggin-knockout mice show significant retardation of hair-follicle induction, and that Noggin neutralizes the inhibitory action of BMP-4 and stimulates hair-follicle induction in embryonic skin organ culture. As a crucial mesenchymal signal that stimulates hair-follicle induction, Noggin operates through antagonistic interactions with BMP-4, which result in upregulation of the transcription factor Lef-1 and the cell-adhesion molecule NCAM, as well as through BMP4-independent downregulation of the 75 kD neurotrophin receptor in the developing hair follicle.

Original languageEnglish (US)
Pages (from-to)158-164
Number of pages7
JournalNature Cell Biology
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

Hair Follicle
Bone Morphogenetic Proteins
Bone Morphogenetic Protein 4
Embryonic Induction
Nerve Growth Factor Receptors
Neural Cell Adhesion Molecules
Ectoderm
Neural Tube
Organ Culture Techniques
Cell Adhesion Molecules
Mesoderm
Knockout Mice
Tooth
Transcription Factors
Up-Regulation
Down-Regulation
Skin

ASJC Scopus subject areas

  • Cell Biology

Cite this

Botchkarev, V. A., Botchkareva, N. V., Roth, W., Nakamura, M., Chen, L. H., Herzog, W., ... Paus, R. (1999). Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nature Cell Biology, 1(3), 158-164. https://doi.org/10.1038/11078

Noggin is a mesenchymally derived stimulator of hair-follicle induction. / Botchkarev, Vladimir A.; Botchkareva, Natalia V.; Roth, Wera; Nakamura, Motonobu; Chen, Ling Hong; Herzog, Wiebke; Lindner, Gerd; McMahon, Jill A.; Peters, Christoph; Lauster, Roland; McMahon, Andrew P.; Paus, Ralf.

In: Nature Cell Biology, Vol. 1, No. 3, 01.01.1999, p. 158-164.

Research output: Contribution to journalArticle

Botchkarev, VA, Botchkareva, NV, Roth, W, Nakamura, M, Chen, LH, Herzog, W, Lindner, G, McMahon, JA, Peters, C, Lauster, R, McMahon, AP & Paus, R 1999, 'Noggin is a mesenchymally derived stimulator of hair-follicle induction', Nature Cell Biology, vol. 1, no. 3, pp. 158-164. https://doi.org/10.1038/11078
Botchkarev VA, Botchkareva NV, Roth W, Nakamura M, Chen LH, Herzog W et al. Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nature Cell Biology. 1999 Jan 1;1(3):158-164. https://doi.org/10.1038/11078
Botchkarev, Vladimir A. ; Botchkareva, Natalia V. ; Roth, Wera ; Nakamura, Motonobu ; Chen, Ling Hong ; Herzog, Wiebke ; Lindner, Gerd ; McMahon, Jill A. ; Peters, Christoph ; Lauster, Roland ; McMahon, Andrew P. ; Paus, Ralf. / Noggin is a mesenchymally derived stimulator of hair-follicle induction. In: Nature Cell Biology. 1999 ; Vol. 1, No. 3. pp. 158-164.
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