NOE Enhancements and T1 Relaxation Times of Phosphorylated Metabolites in Human Calf Muscle at 1.5 Tesla

Truman R. Brown, Radka Stoyanova, Tamela Greenberg, Ravi Srinivasan, Joseph Murphy‐Boesch

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Nuclear Overhauser effect (NOE) enhancements and relaxation times of 31P metabolites in human calf were measured in 12 volunteers (4 men and 8 women) at 1.5 T using a dual tuned four-ring birdcage. The NOE enhancements of inorganic phosphate (P(i)), phosphocreatine (PCr), γ-, α-, and β- nucleoside triphosphate (NTP) from 19 measurements were 0.51 ± 0.10, 0.64 ± 0.03, 0.53 ± 0.03, 0.56 ± 0.08, and 0.47 ± 0.05, respectively. The relaxation times were independent of proton irradiation and from 23 measurements were 3.49 ± 0.35, 4.97 ± 0.58, 4.07 ± 0.36, 2.90 ± 0.25, and 3.61 ± 0.25 s for P(i), PCr, γ-, α-, and β-NTP, respectively. No significant differences between gender and age were observed for either NOE enhancements or relaxation times. Also, among nine volunteers, we observed no significant differences in T1 between the coupled and decoupled cases.

Original languageEnglish (US)
Pages (from-to)417-421
Number of pages5
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Mar 1995
Externally publishedYes


  • decoupled P
  • in vivo human muscle
  • nuclear Overhauser effect (NOE)
  • relaxation times

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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