Nodular cutaneous amyloidoma of the extremity secondary to chronic granulomatous inflammation in setting of sarcoidosis

Victoria L. Billero, Audrey A. Jacobsen, Mariya Miteva, Adam J. Wulkan, Claudio Marasca, Paolo Romanelli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Soft tissue amyloidoma is a rare condition that presents primarily in the abdomen and/or mediastinum and more uncommonly on the extremities. Soft tissue amyloidomas on the extremities have been associated with chronic inflammation, particularly when accompanied by AA-type amyloid deposition as seen in local trauma, surgery, hypertension and diabetes. To our knowledge, this is the first reported case of nodular cutaneous amyloidoma in the setting of systemic and cutaneous sarcoidosis. A 65-year-old woman presented with an asymptomatic subcutaneous nodule above her left lateral malleolus. Histopathology of the lesion showed an inconspicuous epidermis with amorphous eosinophilic material deposited in masses within the entire dermis. Congo red and crystal violet stains were positive. Based on the clinical and pathologic findings she was diagnosed with nodular cutaneous amyloidoma. We hypothesize that this process developed secondary to the chronic granulomatous inflammation of sarcoidosis.

Original languageEnglish (US)
Pages (from-to)801-804
Number of pages4
JournalJournal of Cutaneous Pathology
Volume44
Issue number9
DOIs
StatePublished - Sep 1 2017

Fingerprint

Sarcoidosis
Extremities
Inflammation
Skin
Gentian Violet
Congo Red
Mediastinum
Dermis
Amyloid
Epidermis
Abdomen
Coloring Agents
Hypertension
Wounds and Injuries

Keywords

  • dermatopathology
  • nodular cutaneous amyloidoma
  • primary localized cutaneous amyloidosis
  • sarcoidosis
  • soft tissue amyloidoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Nodular cutaneous amyloidoma of the extremity secondary to chronic granulomatous inflammation in setting of sarcoidosis. / Billero, Victoria L.; Jacobsen, Audrey A.; Miteva, Mariya; Wulkan, Adam J.; Marasca, Claudio; Romanelli, Paolo.

In: Journal of Cutaneous Pathology, Vol. 44, No. 9, 01.09.2017, p. 801-804.

Research output: Contribution to journalArticle

Billero, Victoria L. ; Jacobsen, Audrey A. ; Miteva, Mariya ; Wulkan, Adam J. ; Marasca, Claudio ; Romanelli, Paolo. / Nodular cutaneous amyloidoma of the extremity secondary to chronic granulomatous inflammation in setting of sarcoidosis. In: Journal of Cutaneous Pathology. 2017 ; Vol. 44, No. 9. pp. 801-804.
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