No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease

William K. Scott, Larry H. Yamaoka, Meredyth P. Bass, P. Craig Gaskell, P. Michael Conneally, Gary W. Small, Lindsay A. Farrer, Sanford A. Auerbach, Ann M. Saunders, Allen D. Roses, Jonathan L. Haines, Margaret A. Pericak-Vance

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The low-density lipoprotein receptor-related protein gene (LRP1) is often mentioned as a candidate gene for Alzheimer disease (AD) because of its role as a receptor for apolipoprotein E (apoE), a major genetic risk factor for late-onset familial and sporadic AD. A recent association study of a tetranucleotide repeat polymorphism located 5′ to the LRP1 gene detected an increase in the 87 base pair allele in AD cases compared to unaffected controls. Additionally, an independent study involving a genomic screen for genes associated with late-onset AD identified a region as a possible location of a late-onset AD gene on chromosome 12p between D12S373 and D12S390, about 10 cM proximal to LRP1. We examined 144 late-onset multiplex AD families, 436 sporadic AD cases, and 240 controls and found no evidence of linkage or association of LRP1 and AD. Our data indicate that genetic variation of the LRP1 gene is not a major risk factor in the etiology of AD.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalNeurogenetics
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Keywords

  • Alzheimer disease
  • Apolipoprotein E
  • Chromosome 12
  • Low-density lipoprotein receptor-related protein
  • LRP1 gene

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)

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    Scott, W. K., Yamaoka, L. H., Bass, M. P., Gaskell, P. C., Conneally, P. M., Small, G. W., Farrer, L. A., Auerbach, S. A., Saunders, A. M., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1998). No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease. Neurogenetics, 1(3), 179-183. https://doi.org/10.1007/s100480050026