Abstract
An increasing number of publications are replicating a previously reported disease-marker association but with the risk allele reversed from the previous report. Do such "flip-flop" associations confirm or refute the previous association findings? We hypothesized that these associations may indeed be confirmations but that multilocus effects and variation in interlocus correlations contribute to this flip-flop phenomenon. We used theoretical modeling to demonstrate that flip-flop associations can occur when the investigated variant is correlated, through interactive effects or linkage dis-equilibrium, with a causal variant at another locus, and we show how these findings could explain previous reports of flip-flop associations.
Original language | English (US) |
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Pages (from-to) | 531-538 |
Number of pages | 8 |
Journal | American journal of human genetics |
Volume | 80 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2007 |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)