NO control of mitochondrial function in normal and transformed cells

Celia H. Tengan, Carlos T Moraes

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control of mitochondrial respiration and biogenesis. NO is able to inhibit the electron transport chain, mainly at Complex IV, regulating oxygen consumption and ATP generation, but at the same time, can also induce increase in reactive oxygen and nitrogen species. The presence of reactive species can induce oxidative damage or participate in redox signaling. In this review, we discuss how NO affects mitochondrial respiration and mitochondrial biogenesis, and how it influences the development of mitochondrial deficiency and cancer. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.

Original languageEnglish (US)
JournalBiochimica et Biophysica Acta - Bioenergetics
DOIs
StateAccepted/In press - Nov 28 2016

Fingerprint

Nitric Oxide
Organelle Biogenesis
Respiration
Reactive Nitrogen Species
Neoplasms
Mitochondria
Pathologic Processes
Electron Transport
Oxygen Consumption
Oxidation-Reduction
Reactive Oxygen Species
Adenosine Triphosphate
Oxygen
Molecules

Keywords

  • Cancer
  • Mitochondria
  • Nitric oxide
  • Nitric oxide synthase
  • Respiratory chain

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

Cite this

NO control of mitochondrial function in normal and transformed cells. / Tengan, Celia H.; Moraes, Carlos T.

In: Biochimica et Biophysica Acta - Bioenergetics, 28.11.2016.

Research output: Contribution to journalArticle

@article{5b534bc7dbdc487da335c1f62e49aef4,
title = "NO control of mitochondrial function in normal and transformed cells",
abstract = "Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control of mitochondrial respiration and biogenesis. NO is able to inhibit the electron transport chain, mainly at Complex IV, regulating oxygen consumption and ATP generation, but at the same time, can also induce increase in reactive oxygen and nitrogen species. The presence of reactive species can induce oxidative damage or participate in redox signaling. In this review, we discuss how NO affects mitochondrial respiration and mitochondrial biogenesis, and how it influences the development of mitochondrial deficiency and cancer. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.",
keywords = "Cancer, Mitochondria, Nitric oxide, Nitric oxide synthase, Respiratory chain",
author = "Tengan, {Celia H.} and Moraes, {Carlos T}",
year = "2016",
month = "11",
day = "28",
doi = "10.1016/j.bbabio.2017.02.009",
language = "English (US)",
journal = "Biochimica et Biophysica Acta - Bioenergetics",
issn = "0005-2728",
publisher = "Elsevier",

}

TY - JOUR

T1 - NO control of mitochondrial function in normal and transformed cells

AU - Tengan, Celia H.

AU - Moraes, Carlos T

PY - 2016/11/28

Y1 - 2016/11/28

N2 - Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control of mitochondrial respiration and biogenesis. NO is able to inhibit the electron transport chain, mainly at Complex IV, regulating oxygen consumption and ATP generation, but at the same time, can also induce increase in reactive oxygen and nitrogen species. The presence of reactive species can induce oxidative damage or participate in redox signaling. In this review, we discuss how NO affects mitochondrial respiration and mitochondrial biogenesis, and how it influences the development of mitochondrial deficiency and cancer. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.

AB - Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control of mitochondrial respiration and biogenesis. NO is able to inhibit the electron transport chain, mainly at Complex IV, regulating oxygen consumption and ATP generation, but at the same time, can also induce increase in reactive oxygen and nitrogen species. The presence of reactive species can induce oxidative damage or participate in redox signaling. In this review, we discuss how NO affects mitochondrial respiration and mitochondrial biogenesis, and how it influences the development of mitochondrial deficiency and cancer. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.

KW - Cancer

KW - Mitochondria

KW - Nitric oxide

KW - Nitric oxide synthase

KW - Respiratory chain

UR - http://www.scopus.com/inward/record.url?scp=85013639036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013639036&partnerID=8YFLogxK

U2 - 10.1016/j.bbabio.2017.02.009

DO - 10.1016/j.bbabio.2017.02.009

M3 - Article

JO - Biochimica et Biophysica Acta - Bioenergetics

JF - Biochimica et Biophysica Acta - Bioenergetics

SN - 0005-2728

ER -