NO control of mitochondrial function in normal and transformed cells

Celia H. Tengan, Carlos T. Moraes

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control of mitochondrial respiration and biogenesis. NO is able to inhibit the electron transport chain, mainly at Complex IV, regulating oxygen consumption and ATP generation, but at the same time, can also induce increase in reactive oxygen and nitrogen species. The presence of reactive species can induce oxidative damage or participate in redox signaling. In this review, we discuss how NO affects mitochondrial respiration and mitochondrial biogenesis, and how it influences the development of mitochondrial deficiency and cancer. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.

Original languageEnglish (US)
Pages (from-to)573-581
Number of pages9
JournalBiochimica et Biophysica Acta - Bioenergetics
Volume1858
Issue number8
DOIs
StatePublished - Aug 2017

Keywords

  • Cancer
  • Mitochondria
  • Nitric oxide
  • Nitric oxide synthase
  • Respiratory chain

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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