No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial alzheimer disease

W. K. Scott, L. H. Yamaoka, P. A. Locke, B. L. Rosi, P. C. Gaskell, A. M. Saunders, P. M. Conneally, G. W. Small, L. A. Farrer, J. H. Growdon, A. D. Roses, M. A. Pericak-Vance, J. L. Haines

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Recent reports have shown an association between an intronic polymorphism of the presenilin-1 (PSEN1) gene and late-onset (age at onset > 65) familial and sporadic (no family history) Alzheimer disease (AD). The reported association was independent of the effect of the only previously identified gene associated with late-onset AD, APOE. Blood samples were obtained froth members of 122 multiplex AD families, 42 unrelated cases of AD with positive family histories of dementia, 456 sporadic cases of AD, and 317 controls of similar ages at examination to the cases. These samples were genotyped for an intronic polymorphism of the PSEN1 gene, located 3' to exon 8, and the data analyzed for evidence of association or linkage. The samples were also genotyped for APOE and the data analyzed to see if the association or linkage changed when controlling for APOE genotype. There was no statistically significant increase (at α = .01) in allele 1 (199 bp) or genotype 1/1 in the sporadic AD cases, or in a random sample of one affected from each multiplex family, compared to controls. When examining the effect of the PSEN1 polymorphism while controlling for APOE genotype, APOE genotype was strongly associated with AD, but the PSEN1 polymorphism genotype was not. Model-trait dependent (lod score) and independent (SimIBD) methods detected no evidence of linkage between PSEN1 and AD. In this independent dataset, the previously reported association between the intronic PSEN1 polymorphism and AD cannot be confirmed, and the conclusion that PSEN1 is a major susceptibility gene for late onset AD is not supported.

Original languageEnglish (US)
Pages (from-to)307-315
Number of pages9
JournalGenetic Epidemiology
Volume14
Issue number3
DOIs
StatePublished - Jun 19 1997
Externally publishedYes

Keywords

  • APOE
  • Dementia
  • Genetics
  • Linkage analysis
  • PSEN1

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

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    Scott, W. K., Yamaoka, L. H., Locke, P. A., Rosi, B. L., Gaskell, P. C., Saunders, A. M., Conneally, P. M., Small, G. W., Farrer, L. A., Growdon, J. H., Roses, A. D., Pericak-Vance, M. A., & Haines, J. L. (1997). No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial alzheimer disease. Genetic Epidemiology, 14(3), 307-315. https://doi.org/10.1002/(SICI)1098-2272(1997)14:3<307::AID-GEPI8>3.0.CO;2-1