No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample

Danielle Fallin, Amy Kundtz, Terrence Town, Ann C. Gauntlett, Ranjan Duara, William Barker, Fiona Crawford, Michael Mullan

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

It is now commonly known that possession of the ξ4 allele of the apolipoprotein E (APOE) gene confers an increased risk for both familial and sporadic Alzheimer's disease (AD), in a dose-dependent way. Other genes that may play a role in AD, either through independent association with the disease or through modification of the existing APOE risk, have been reported with conflicting results. One such gene, the low density lipoprotein receptor-related protein (LRP) gene, was recently reported by two groups to be associated with AD, although the groups identified different risk- conferring alleles. Both studies were based on clinic-derived AD populations (one American, one French), and both reported only marginally significant results. We have genotyped a community-based AD and control population at this LRP polymorphism and find no association between the variants at that polymorphism and the occurrence of AD. Further, despite the biochemical relationship between LRP and the ApoE protein, we find no significant statistical interaction between the alleles at these loci.

Original languageEnglish (US)
Pages (from-to)145-147
Number of pages3
JournalNeuroscience Letters
Volume233
Issue number2-3
DOIs
StatePublished - Sep 19 1997

Keywords

  • Alzheimer's disease risk
  • Apolipoprotein
  • Genetic interaction

ASJC Scopus subject areas

  • Neuroscience(all)

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