No Association between the APOE Gene and Autism

K. L. Raiford, Y. Shao, I. C. Allen, Eden R Martin, M. M. Menold, H. H. Wright, R. K. Abramson, G. Worley, G. R. DeLong, Jeffery M Vance, Michael Cuccaro, John Gilbert, Margaret A Pericak-Vance

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Autism is a neurodevelopmental disorder characterized by stereotypic and repetitive behavior and interests, together with social and communicative deficiencies. The results of several genomic screens suggest the presence of an autism susceptibility locus on chromosome 19p13.2-q13.4. The apolipoprotein E (APOE) gene on chromosome 19 encodes for a protein, apoE, whose different isoforms (E2, E3, E4) influence neuronal growth. APOE participates in lipid transport and metabolism, repair, growth, and maintenance of axons and myelin during neuronal development. The APOE protein competes with the Reelin protein for VLDL/APOER2 receptor binding. Several studies have reported evidence for an association between autism and the Reelin gene. Based on these data we tested for association between APOE and autism using family-based association methods in a data set of 322 autism families. Three promoter, one intronic, and one 3′ UTR single nucleotide polymorphisms (SNPs) in the APOE gene (-491a/t, -427c/t, -219g/t, 113c/g, and 5361c/t) as well as the APOE functional polymorphism (E2, E3, E4) were examined and failed to reveal significant evidence that autism is associated with APOE.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume125 B
Issue number1
StatePublished - Feb 15 2004
Externally publishedYes

Fingerprint

Apolipoproteins E
Autistic Disorder
Genes
Chromosomes, Human, Pair 19
3' Untranslated Regions
Growth
Myelin Sheath
Lipid Metabolism
Single Nucleotide Polymorphism
Axons
Protein Isoforms
Proteins
Chromosomes
Maintenance

Keywords

  • APOE
  • Association
  • Autism

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

No Association between the APOE Gene and Autism. / Raiford, K. L.; Shao, Y.; Allen, I. C.; Martin, Eden R; Menold, M. M.; Wright, H. H.; Abramson, R. K.; Worley, G.; DeLong, G. R.; Vance, Jeffery M; Cuccaro, Michael; Gilbert, John; Pericak-Vance, Margaret A.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 125 B, No. 1, 15.02.2004, p. 57-60.

Research output: Contribution to journalArticle

Raiford, KL, Shao, Y, Allen, IC, Martin, ER, Menold, MM, Wright, HH, Abramson, RK, Worley, G, DeLong, GR, Vance, JM, Cuccaro, M, Gilbert, J & Pericak-Vance, MA 2004, 'No Association between the APOE Gene and Autism', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 125 B, no. 1, pp. 57-60.
Raiford KL, Shao Y, Allen IC, Martin ER, Menold MM, Wright HH et al. No Association between the APOE Gene and Autism. American Journal of Medical Genetics - Neuropsychiatric Genetics. 2004 Feb 15;125 B(1):57-60.
Raiford, K. L. ; Shao, Y. ; Allen, I. C. ; Martin, Eden R ; Menold, M. M. ; Wright, H. H. ; Abramson, R. K. ; Worley, G. ; DeLong, G. R. ; Vance, Jeffery M ; Cuccaro, Michael ; Gilbert, John ; Pericak-Vance, Margaret A. / No Association between the APOE Gene and Autism. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2004 ; Vol. 125 B, No. 1. pp. 57-60.
@article{450cd47e81f4478d87a9dd8dd9d2fb23,
title = "No Association between the APOE Gene and Autism",
abstract = "Autism is a neurodevelopmental disorder characterized by stereotypic and repetitive behavior and interests, together with social and communicative deficiencies. The results of several genomic screens suggest the presence of an autism susceptibility locus on chromosome 19p13.2-q13.4. The apolipoprotein E (APOE) gene on chromosome 19 encodes for a protein, apoE, whose different isoforms (E2, E3, E4) influence neuronal growth. APOE participates in lipid transport and metabolism, repair, growth, and maintenance of axons and myelin during neuronal development. The APOE protein competes with the Reelin protein for VLDL/APOER2 receptor binding. Several studies have reported evidence for an association between autism and the Reelin gene. Based on these data we tested for association between APOE and autism using family-based association methods in a data set of 322 autism families. Three promoter, one intronic, and one 3′ UTR single nucleotide polymorphisms (SNPs) in the APOE gene (-491a/t, -427c/t, -219g/t, 113c/g, and 5361c/t) as well as the APOE functional polymorphism (E2, E3, E4) were examined and failed to reveal significant evidence that autism is associated with APOE.",
keywords = "APOE, Association, Autism",
author = "Raiford, {K. L.} and Y. Shao and Allen, {I. C.} and Martin, {Eden R} and Menold, {M. M.} and Wright, {H. H.} and Abramson, {R. K.} and G. Worley and DeLong, {G. R.} and Vance, {Jeffery M} and Michael Cuccaro and John Gilbert and Pericak-Vance, {Margaret A}",
year = "2004",
month = "2",
day = "15",
language = "English",
volume = "125 B",
pages = "57--60",
journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - No Association between the APOE Gene and Autism

AU - Raiford, K. L.

AU - Shao, Y.

AU - Allen, I. C.

AU - Martin, Eden R

AU - Menold, M. M.

AU - Wright, H. H.

AU - Abramson, R. K.

AU - Worley, G.

AU - DeLong, G. R.

AU - Vance, Jeffery M

AU - Cuccaro, Michael

AU - Gilbert, John

AU - Pericak-Vance, Margaret A

PY - 2004/2/15

Y1 - 2004/2/15

N2 - Autism is a neurodevelopmental disorder characterized by stereotypic and repetitive behavior and interests, together with social and communicative deficiencies. The results of several genomic screens suggest the presence of an autism susceptibility locus on chromosome 19p13.2-q13.4. The apolipoprotein E (APOE) gene on chromosome 19 encodes for a protein, apoE, whose different isoforms (E2, E3, E4) influence neuronal growth. APOE participates in lipid transport and metabolism, repair, growth, and maintenance of axons and myelin during neuronal development. The APOE protein competes with the Reelin protein for VLDL/APOER2 receptor binding. Several studies have reported evidence for an association between autism and the Reelin gene. Based on these data we tested for association between APOE and autism using family-based association methods in a data set of 322 autism families. Three promoter, one intronic, and one 3′ UTR single nucleotide polymorphisms (SNPs) in the APOE gene (-491a/t, -427c/t, -219g/t, 113c/g, and 5361c/t) as well as the APOE functional polymorphism (E2, E3, E4) were examined and failed to reveal significant evidence that autism is associated with APOE.

AB - Autism is a neurodevelopmental disorder characterized by stereotypic and repetitive behavior and interests, together with social and communicative deficiencies. The results of several genomic screens suggest the presence of an autism susceptibility locus on chromosome 19p13.2-q13.4. The apolipoprotein E (APOE) gene on chromosome 19 encodes for a protein, apoE, whose different isoforms (E2, E3, E4) influence neuronal growth. APOE participates in lipid transport and metabolism, repair, growth, and maintenance of axons and myelin during neuronal development. The APOE protein competes with the Reelin protein for VLDL/APOER2 receptor binding. Several studies have reported evidence for an association between autism and the Reelin gene. Based on these data we tested for association between APOE and autism using family-based association methods in a data set of 322 autism families. Three promoter, one intronic, and one 3′ UTR single nucleotide polymorphisms (SNPs) in the APOE gene (-491a/t, -427c/t, -219g/t, 113c/g, and 5361c/t) as well as the APOE functional polymorphism (E2, E3, E4) were examined and failed to reveal significant evidence that autism is associated with APOE.

KW - APOE

KW - Association

KW - Autism

UR - http://www.scopus.com/inward/record.url?scp=0942290689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0942290689&partnerID=8YFLogxK

M3 - Article

VL - 125 B

SP - 57

EP - 60

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 1

ER -