No association between subjective memory complaints and apolipoprotein E genotype in cognitively intact elderly

Dylan G. Harwood, Warren W. Barker, Raymond L. Ownby, Michael Mullan, Ranjan Duara

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective. This cross-sectional study examined the relationship between subjective memory complaints and the apolipoprotein epsilon 4 allele (E4), a genetic risk factor for Alzheimer's disease (AD), among cognitively normal subjects identified from a community memory screening. Design. The sample comprised 232 consecutive white non-Hispanic older adults who presented to a free community-based memory-screening program at a University affiliated memory disorders center. Participants were classified as cognitively normal based on scores on the age and educated adjusted Folstein Mini-Mental Status Exam (MMSAdj) and a brief Delayed Verbal Recall Test (DRT). Subjects were assessed for APOE genotype, subjective memory complaints (Memory Questionnaire, MQ), depressive symptoms (Hamilton Depression Rating Scale, HDRS), and history of four major medical conditions that have been associated with memory loss (stroke/transient ischemic attack [TIA], atherosclerotic heart disease, hypertension, and diabetes). A hierarchical regression analysis was performed to examine the association between APOE genotype and memory complaints after controlling for a host of potential confounding factors. Results. The APOE E4 allele frequency for cognitively normal subjects was 0.13. Subjective memory complaints were predicted by depressive symptoms and a history of stroke/TIA. They were not associated with APOE genotype, MMSAdj score, DRT score, age, education, gender, and reported history of atherosclerotic heart disease, hypertension, or diabetes. Conclusions. The results did not suggest an association between subjective memory complaints and the APOE E4 allele in this sample of cognitively intact subjects. This indicates that memory complaints may confer risk for future dementia through pathways independent of APOE genotype. The results also show that older adults with memory complaints are at increased risk for underlying depression.

Original languageEnglish
Pages (from-to)1131-1139
Number of pages9
JournalInternational Journal of Geriatric Psychiatry
Volume19
Issue number12
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Fingerprint

Apolipoproteins E
Genotype
Alleles
Depression
Transient Ischemic Attack
Memory Disorders
Heart Diseases
Stroke
Hypertension
Apolipoproteins
Gene Frequency
Dementia
Alzheimer Disease
Cross-Sectional Studies
Regression Analysis
Education

Keywords

  • Apolipoprotein E genotype
  • Memory complaints
  • Memory impairment

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

No association between subjective memory complaints and apolipoprotein E genotype in cognitively intact elderly. / Harwood, Dylan G.; Barker, Warren W.; Ownby, Raymond L.; Mullan, Michael; Duara, Ranjan.

In: International Journal of Geriatric Psychiatry, Vol. 19, No. 12, 01.12.2004, p. 1131-1139.

Research output: Contribution to journalArticle

Harwood, Dylan G. ; Barker, Warren W. ; Ownby, Raymond L. ; Mullan, Michael ; Duara, Ranjan. / No association between subjective memory complaints and apolipoprotein E genotype in cognitively intact elderly. In: International Journal of Geriatric Psychiatry. 2004 ; Vol. 19, No. 12. pp. 1131-1139.
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