No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets

Xueying Liang, Nathalie Schnetz-Boutaud, Jackie Bartlett, Melissa J. Allen, Harry Gwirtsman, Don E. Schmechel, Regina M. Carney, John Gilbert, Margaret A Pericak-Vance, Jonathan L. Haines

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

SNP rs498055 in the predicted gene LOC439999 on chromosome 10 was recently identified as being strongly associated with late-onset Alzheimer disease (LOAD). This SNP falls within a chromosomal region that has engendered continued interest generated from both preliminary genetic linkage and candidate gene studies. To independently evaluate this interesting candidate SNP we examined four independent datasets, three family-based and one case-control. All the cases were late-onset AD Caucasian patients with minimum age at onset ≥ 60 years. None of the three family samples or the combined family-based dataset showed association in either allelic or genotypic family-based association tests at p < 0.05. Both original and OSA two-point LOD scores were calculated. However, there was no evidence indicating linkage no matter what covariates were applied (the highest LOD score was 0.82). The case-control dataset did not demonstrate any association between this SNP and AD (all p-values > 0.52). Our results do not confirm the previous association, but are consistent with a more recent negative association result that used family-based association tests to examine the effect of this SNP in two family datasets. Thus we conclude that rs498055 is not associated with an increased risk of LOAD.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalAnnals of Human Genetics
Volume72
Issue number1
DOIs
StatePublished - Jan 1 2008

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Chromosomes, Human, Pair 10
Single Nucleotide Polymorphism
Alzheimer Disease
Genetic Linkage
Age of Onset
Genes
Datasets

Keywords

  • Alzheimer disease
  • Association
  • Chromosome10
  • rs498055
  • SNP

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Liang, X., Schnetz-Boutaud, N., Bartlett, J., Allen, M. J., Gwirtsman, H., Schmechel, D. E., ... Haines, J. L. (2008). No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets. Annals of Human Genetics, 72(1), 141-144. https://doi.org/10.1111/j.1469-1809.2007.00394.x

No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets. / Liang, Xueying; Schnetz-Boutaud, Nathalie; Bartlett, Jackie; Allen, Melissa J.; Gwirtsman, Harry; Schmechel, Don E.; Carney, Regina M.; Gilbert, John; Pericak-Vance, Margaret A; Haines, Jonathan L.

In: Annals of Human Genetics, Vol. 72, No. 1, 01.01.2008, p. 141-144.

Research output: Contribution to journalArticle

Liang, X, Schnetz-Boutaud, N, Bartlett, J, Allen, MJ, Gwirtsman, H, Schmechel, DE, Carney, RM, Gilbert, J, Pericak-Vance, MA & Haines, JL 2008, 'No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets', Annals of Human Genetics, vol. 72, no. 1, pp. 141-144. https://doi.org/10.1111/j.1469-1809.2007.00394.x
Liang, Xueying ; Schnetz-Boutaud, Nathalie ; Bartlett, Jackie ; Allen, Melissa J. ; Gwirtsman, Harry ; Schmechel, Don E. ; Carney, Regina M. ; Gilbert, John ; Pericak-Vance, Margaret A ; Haines, Jonathan L. / No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets. In: Annals of Human Genetics. 2008 ; Vol. 72, No. 1. pp. 141-144.
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