No association between α1-antichymotrypsin and familial Alzheimer's disease

Jonathan L. Haines, Meredyth L. Pritchard, Ann M. Saunders, Joellen M. Schildkraut, John H. Growdon, Peter C. Gaskell, Lindsay A. Farrer, Sanford A. Auerbach, James F. Gusella, Patricia A. Locke, Barbara L. Rosi, Larry Yamaoka, Gary W. Small, P. Michael Conneally, Allen D. Roses, Margaret Pericak-Vance

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Alzheimer's disease (AD) is the most common mid to late age-of-onset neurodegenerative disorder. AD has a strong and complex genetic etiology, and multiple genes, acting independently and/or interacting, likely affect the risk of developing AD. Several genes involved with AD already have been described, but only the APOE gene on chromosome 19q has been shown to affect the risk of the most common form of AD, occurring with onset over the age of 65. Because a substantial portion of late-onset AD is not explained by APOE, other genes affecting late-onset AD likely occur. These could act either independently or perhaps interact with APOE. α1-antichymotrypsin (ACT) is a major component of the amyloid plaques found in the brains of AD patients and may play a role in the pathophysiology of AD. It has been proposed that a specific polymorphism within the ACT gene interacts with APOE to increase the risk of developing AD. Our results do not confirm this finding.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume802
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Haines, J. L., Pritchard, M. L., Saunders, A. M., Schildkraut, J. M., Growdon, J. H., Gaskell, P. C., Farrer, L. A., Auerbach, S. A., Gusella, J. F., Locke, P. A., Rosi, B. L., Yamaoka, L., Small, G. W., Conneally, P. M., Roses, A. D., & Pericak-Vance, M. (1996). No association between α1-antichymotrypsin and familial Alzheimer's disease. Annals of the New York Academy of Sciences, 802, 35-41. https://doi.org/10.1111/j.1749-6632.1996.tb32596.x