No association between α1-antichymotrypsin and familial Alzheimer's disease

Jonathan L. Haines, Meredyth L. Pritchard, Ann M. Saunders, Joellen M. Schildkraut, John H. Growdon, Peter C. Gaskell, Lindsay A. Farrer, Sanford A. Auerbach, James F. Gusella, Patricia A. Locke, Barbara L. Rosi, Larry Yamaoka, Gary W. Small, P. Michael Conneally, Allen D. Roses, Margaret A Pericak-Vance

Research output: Contribution to journalArticle

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Abstract

Alzheimer's disease (AD) is the most common mid to late age-of-onset neurodegenerative disorder. AD has a strong and complex genetic etiology, and multiple genes, acting independently and/or interacting, likely affect the risk of developing AD. Several genes involved with AD already have been described, but only the APOE gene on chromosome 19q has been shown to affect the risk of the most common form of AD, occurring with onset over the age of 65. Because a substantial portion of late-onset AD is not explained by APOE, other genes affecting late-onset AD likely occur. These could act either independently or perhaps interact with APOE. α1-antichymotrypsin (ACT) is a major component of the amyloid plaques found in the brains of AD patients and may play a role in the pathophysiology of AD. It has been proposed that a specific polymorphism within the ACT gene interacts with APOE to increase the risk of developing AD. Our results do not confirm this finding.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume802
DOIs
StatePublished - Dec 1 1996
Externally publishedYes

Fingerprint

Alzheimer Disease
Genes
Age of Onset
Alzheimer Disease, Familial, 1
Familial
Alzheimer's Disease
Amyloid Plaques
Brain Diseases
Chromosomes
Polymorphism
Amyloid
Neurodegenerative Diseases
Brain
Gene
Onset

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

No association between α1-antichymotrypsin and familial Alzheimer's disease. / Haines, Jonathan L.; Pritchard, Meredyth L.; Saunders, Ann M.; Schildkraut, Joellen M.; Growdon, John H.; Gaskell, Peter C.; Farrer, Lindsay A.; Auerbach, Sanford A.; Gusella, James F.; Locke, Patricia A.; Rosi, Barbara L.; Yamaoka, Larry; Small, Gary W.; Conneally, P. Michael; Roses, Allen D.; Pericak-Vance, Margaret A.

In: Annals of the New York Academy of Sciences, Vol. 802, 01.12.1996, p. 35-41.

Research output: Contribution to journalArticle

Haines, JL, Pritchard, ML, Saunders, AM, Schildkraut, JM, Growdon, JH, Gaskell, PC, Farrer, LA, Auerbach, SA, Gusella, JF, Locke, PA, Rosi, BL, Yamaoka, L, Small, GW, Conneally, PM, Roses, AD & Pericak-Vance, MA 1996, 'No association between α1-antichymotrypsin and familial Alzheimer's disease', Annals of the New York Academy of Sciences, vol. 802, pp. 35-41. https://doi.org/10.1111/j.1749-6632.1996.tb32596.x
Haines, Jonathan L. ; Pritchard, Meredyth L. ; Saunders, Ann M. ; Schildkraut, Joellen M. ; Growdon, John H. ; Gaskell, Peter C. ; Farrer, Lindsay A. ; Auerbach, Sanford A. ; Gusella, James F. ; Locke, Patricia A. ; Rosi, Barbara L. ; Yamaoka, Larry ; Small, Gary W. ; Conneally, P. Michael ; Roses, Allen D. ; Pericak-Vance, Margaret A. / No association between α1-antichymotrypsin and familial Alzheimer's disease. In: Annals of the New York Academy of Sciences. 1996 ; Vol. 802. pp. 35-41.
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