Nitrosamine formation in bladder infections and its role in the etiology of bladder cancer

J. L. Radomski, D. Greenwald, W. L. Hearn, Norman L Block, F. M. Woods

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Dimethylnitrosamine, a powerful carcinogen, is produced in the urine of patients with urinary tract infections of Proteus mirabilis and Escherichia coli when nitrite is present. Treatment with tetracycline antibiotics does not enhance the concentration of this carcinogen but, rather, sharply reduces it. The results emphasize the importance of proper antibiotic therapy for the infections to reduce the possibility of the subsequent development of bladder cancer.

Original languageEnglish
Pages (from-to)48-50
Number of pages3
JournalJournal of Urology
Volume120
Issue number1
StatePublished - Dec 1 1978
Externally publishedYes

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Nitrosamines
Urinary Bladder Neoplasms
Carcinogens
Urinary Bladder
Anti-Bacterial Agents
Dimethylnitrosamine
Proteus mirabilis
Nitrites
Infection
Tetracycline
Urinary Tract Infections
Urine
Escherichia coli
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Radomski, J. L., Greenwald, D., Hearn, W. L., Block, N. L., & Woods, F. M. (1978). Nitrosamine formation in bladder infections and its role in the etiology of bladder cancer. Journal of Urology, 120(1), 48-50.

Nitrosamine formation in bladder infections and its role in the etiology of bladder cancer. / Radomski, J. L.; Greenwald, D.; Hearn, W. L.; Block, Norman L; Woods, F. M.

In: Journal of Urology, Vol. 120, No. 1, 01.12.1978, p. 48-50.

Research output: Contribution to journalArticle

Radomski, JL, Greenwald, D, Hearn, WL, Block, NL & Woods, FM 1978, 'Nitrosamine formation in bladder infections and its role in the etiology of bladder cancer', Journal of Urology, vol. 120, no. 1, pp. 48-50.
Radomski JL, Greenwald D, Hearn WL, Block NL, Woods FM. Nitrosamine formation in bladder infections and its role in the etiology of bladder cancer. Journal of Urology. 1978 Dec 1;120(1):48-50.
Radomski, J. L. ; Greenwald, D. ; Hearn, W. L. ; Block, Norman L ; Woods, F. M. / Nitrosamine formation in bladder infections and its role in the etiology of bladder cancer. In: Journal of Urology. 1978 ; Vol. 120, No. 1. pp. 48-50.
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