Nitrosamine formation in bladder infections and its role in the etiology of bladder cancer

J. L. Radomski, D. Greenwald, W. L. Hearn, N. L. Block, F. M. Woods

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Dimethylnitrosamine, a powerful carcinogen, is produced in the urine of patients with urinary tract infections of Proteus mirabilis and Escherichia coli when nitrite is present. Treatment with tetracycline antibiotics does not enhance the concentration of this carcinogen but, rather, sharply reduces it. The results emphasize the importance of proper antibiotic therapy for the infections to reduce the possibility of the subsequent development of bladder cancer.

Original languageEnglish (US)
Pages (from-to)48-50
Number of pages3
JournalUnknown Journal
Volume120
Issue number1
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Urology

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    Radomski, J. L., Greenwald, D., Hearn, W. L., Block, N. L., & Woods, F. M. (1978). Nitrosamine formation in bladder infections and its role in the etiology of bladder cancer. Unknown Journal, 120(1), 48-50. https://doi.org/10.1016/S0022-5347(17)57035-4