Nitrogen sparing effect of essential amino acids in uremia

C. Abitol, M. Holliday

Research output: Contribution to journalArticlepeer-review


This study was designed to determine whether essential amino acids administered during night time fasting would improve the nutritional status of uremic children. Seven children (8-14 yr) with mean SUN=107 mgn% were given 10% glucose and essential amino acid nitrogen (EAAN) to provide 0.25-0.5 gm/K/night for 5 nights following a control period of one night. Ad libitum diet provided a mean of 69 Kcal/K/day (Range 26-109) and 0.68 gm Protein/k/day (Range 0.12-1.37). Urea production (UrP)/24 hr was determined from change in urea nitrogen pool and urinary excretion. Apparent protein synthesis (PrS) was determined as the difference between total nitrogen intake (NI) and UrP. Results were evaluated by testing the correlation of nitrogen intake with urea production and apparent protein synthesis. Infusion of EAAN in uremic patients may promote protein synthesis without increasing urea production.

Original languageEnglish (US)
Pages (from-to)No.264
JournalPediatric Research
Issue number4
StatePublished - Jan 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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