Abstract
We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.
| Original language | English |
|---|---|
| Pages (from-to) | 1683-1686 |
| Number of pages | 4 |
| Journal | Journal of Rheumatology |
| Volume | 19 |
| Issue number | 11 |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
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Keywords
- nitrogen mustard
- rheumatoid arthritis
ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Nitrogen mustard as induction therapy for rheumatoid arthritis : Clinical and immunologic effects. / Danao, T.; Ropos, T.; Wilke, W.; Segal, A.; Calabrese, L.; Valenzuela, R.; Gragg, L.; Clough, J.
In: Journal of Rheumatology, Vol. 19, No. 11, 01.01.1992, p. 1683-1686.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nitrogen mustard as induction therapy for rheumatoid arthritis
T2 - Clinical and immunologic effects
AU - Danao, T.
AU - Ropos, T.
AU - Wilke, W.
AU - Segal, A.
AU - Calabrese, L.
AU - Valenzuela, R.
AU - Gragg, L.
AU - Clough, J.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.
AB - We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.
KW - nitrogen mustard
KW - rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=0026464964&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026464964&partnerID=8YFLogxK
M3 - Article
C2 - 1491386
AN - SCOPUS:0026464964
VL - 19
SP - 1683
EP - 1686
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 11
ER -