Abstract
We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1683-1686 |
| Number of pages | 4 |
| Journal | Journal of Rheumatology |
| Volume | 19 |
| Issue number | 11 |
| State | Published - Jan 1 1992 |
Keywords
- nitrogen mustard
- rheumatoid arthritis
ASJC Scopus subject areas
- Immunology
- Rheumatology
Fingerprint Dive into the research topics of 'Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects'. Together they form a unique fingerprint.
Cite this
Danao, T., Ropos, T., Wilke, W., Segal, A., Calabrese, L., Valenzuela, R., Gragg, L., & Clough, J. (1992). Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects. Journal of Rheumatology, 19(11), 1683-1686.