Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects

T. Danao, T. Ropos, W. Wilke, A. Segal, L. Calabrese, R. Valenzuela, L. Gragg, J. Clough

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.

Original languageEnglish (US)
Pages (from-to)1683-1686
Number of pages4
JournalJournal of Rheumatology
Volume19
Issue number11
StatePublished - Jan 1 1992

Keywords

  • nitrogen mustard
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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    Danao, T., Ropos, T., Wilke, W., Segal, A., Calabrese, L., Valenzuela, R., Gragg, L., & Clough, J. (1992). Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects. Journal of Rheumatology, 19(11), 1683-1686.