Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects

T. Danao, T. Ropos, W. Wilke, A. Segal, L. Calabrese, R. Valenzuela, L. Gragg, J. Clough

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.

Original languageEnglish
Pages (from-to)1683-1686
Number of pages4
JournalJournal of Rheumatology
Volume19
Issue number11
StatePublished - Jan 1 1992
Externally publishedYes

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Mechlorethamine
Rheumatoid Arthritis
T-Lymphocytes
Ideal Body Weight
Immune System Diseases
Pain Measurement
Joints
Therapeutics

Keywords

  • nitrogen mustard
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Danao, T., Ropos, T., Wilke, W., Segal, A., Calabrese, L., Valenzuela, R., ... Clough, J. (1992). Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects. Journal of Rheumatology, 19(11), 1683-1686.

Nitrogen mustard as induction therapy for rheumatoid arthritis : Clinical and immunologic effects. / Danao, T.; Ropos, T.; Wilke, W.; Segal, A.; Calabrese, L.; Valenzuela, R.; Gragg, L.; Clough, J.

In: Journal of Rheumatology, Vol. 19, No. 11, 01.01.1992, p. 1683-1686.

Research output: Contribution to journalArticle

Danao, T, Ropos, T, Wilke, W, Segal, A, Calabrese, L, Valenzuela, R, Gragg, L & Clough, J 1992, 'Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects', Journal of Rheumatology, vol. 19, no. 11, pp. 1683-1686.
Danao T, Ropos T, Wilke W, Segal A, Calabrese L, Valenzuela R et al. Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects. Journal of Rheumatology. 1992 Jan 1;19(11):1683-1686.
Danao, T. ; Ropos, T. ; Wilke, W. ; Segal, A. ; Calabrese, L. ; Valenzuela, R. ; Gragg, L. ; Clough, J. / Nitrogen mustard as induction therapy for rheumatoid arthritis : Clinical and immunologic effects. In: Journal of Rheumatology. 1992 ; Vol. 19, No. 11. pp. 1683-1686.
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