Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects

T. Danao; T. Ropos; W. Wilke; A. Segal; L. Calabrese; R. Valenzuela; L. Gragg; J. Clough

Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects

T. Danao, T. Ropos, W. Wilke, A. Segal, L. Calabrese, R. Valenzuela, L. Gragg, J. Clough

Pathology

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3 Scopus citations

Abstract

We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN₂) and monitored clinical and immunologic variables. HN₂, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN₂ is effective for rapidly gaining control of active RA. This effect is T cell specific.

Original language	English (US)
Pages (from-to)	1683-1686
Number of pages	4
Journal	Journal of Rheumatology
Volume	19
Issue number	11
State	Published - Jan 1 1992

Keywords

nitrogen mustard
rheumatoid arthritis

ASJC Scopus subject areas

Immunology
Rheumatology

Cite this

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abstract = "We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.",

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T1 - Nitrogen mustard as induction therapy for rheumatoid arthritis

T2 - Clinical and immunologic effects

AU - Danao, T.

AU - Ropos, T.

AU - Wilke, W.

AU - Segal, A.

AU - Calabrese, L.

AU - Valenzuela, R.

AU - Gragg, L.

AU - Clough, J.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.

AB - We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.

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Nitrogen mustard as induction therapy for rheumatoid arthritis: Clinical and immunologic effects

Abstract

Keywords

ASJC Scopus subject areas

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