Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats

M. R. Pierce, C. A. Voelker, S. Bustamante, S. M. Olister, X. J. Zhang, D. A. Clark, M. J.S. Miller, I. R.S. Sosenko

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We evaluated the effects of sustained perinatal inhibition of NO synthase (NOS) on hyperoxia induced lung injury in newborn rats. N(G)-nitro-L-arginine-methyl-ester (L-NAME) or untreated water was administered to pregnant rats for the final 7 days of gestation and during lactation; followed by postnatal exposure to hyperoxia (>95% O2) or room air. The survival rate of L-NAME treated pups when placed in >95% O2 at birth was significantly lower than controls from day 4 (L-NAME, 87%; control pups, 100%, p < 0.05) to 14 (L-NAME, 0%; control pups, 53%, P < 0.05). Foetal pulmonary artery vasoconstriction was induced by L-NAME with a decrease in internal diameter from 0.88 ± 0.03 mm to 0.64 ± 0.01 mm in control us. L-NAME groups (P < 0.05), respectively. We conclude that perinatal NOS inhibition results in pulmonary artery vasoconstriction and a decreased tolerance to hyperoxia induced lung injury in newborn rats.

Original languageEnglish (US)
Pages (from-to)431-436
Number of pages6
JournalMediators of Inflammation
Volume4
Issue number6
DOIs
StatePublished - 1995

Keywords

  • Antioxidant enzyme
  • Hyperoxia
  • N(G)-nitro-L-arginine-methyl-ester
  • Nitric oxide
  • Nitric oxide synthase
  • Pulmonary artery

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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  • Cite this

    Pierce, M. R., Voelker, C. A., Bustamante, S., Olister, S. M., Zhang, X. J., Clark, D. A., Miller, M. J. S., & Sosenko, I. R. S. (1995). Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats. Mediators of Inflammation, 4(6), 431-436. https://doi.org/10.1155/S096293519500069X