Nitric oxide synthase and hypertension

Baudouin Leclercq, Edgar A. Jaimes, Leopoldo Raij

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Nitric oxide, the metabolic product of L-arginine by the enzyme nitric oxide synthase, plays a pivotal role in the regulation of vascular homeostasis. Its complex interaction with the autocrine and paracrine systems, particularly angiotensin II, modulates vasoconstriction and vasodilatation as well as the architectural remodeling of the vascular bed. The major vascular hormones known to be involved are angiotensin II and endothelin-1. Upregulation of endothelin-1, a potent molecule, appears to be a consequence of the nitric oxide-angiotensin II imbalance that contributes to end-organ injury. Increased oxidative stress, common to different diseases including diabetes mellitus and hypertension, is also a determinant player in the interaction between angiotensin II and nitric oxide. The influence of a relative malfunction of the nitric oxide system on the vascular tone and vascular structure, and the effects of hypertension on this system, are discussed.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalCurrent Opinion in Nephrology and Hypertension
Issue number2
StatePublished - Mar 14 2002

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology


Dive into the research topics of 'Nitric oxide synthase and hypertension'. Together they form a unique fingerprint.

Cite this