Abstract
The nitric oxide (NO) signaling pathway participates in regulating numerous facets of cardiovascular function, including myocardial contractility, ventricular relaxation, mitochondrial respiration, and endothelial function. As such, this pathway contributes to numerous facets of cardiovascular pathophysiology. NO plays a main role in both regulating and responding to the redox state of the cell (nitroso-redox balance), which targets calcium handling, contractile mechanisms, vasoactive mechanisms, as well as stem cell aspects involved in cardiac regeneration. Thus, the interaction between NO and reactive oxygen species (ROS), the nitroso-redox signaling pathway, is critically important in cardiac physiology and pathophysiology and a fundamental therapeutic target. This chapter will address the cardiovascular implications of the biological balance between NO and ROS as they relate to cardiac physiology and the pathophysiology of heart disease and offer insights for the development of new therapeutic strategies.
| Original language | English (US) |
|---|---|
| Title of host publication | Nitric Oxide |
| Subtitle of host publication | Biology and Pathobiology: Third Edition |
| Publisher | Elsevier Inc. |
| Pages | 313-338 |
| Number of pages | 26 |
| ISBN (Print) | 9780128042731 |
| DOIs | |
| State | Published - Jan 1 2017 |
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Keywords
- Angiogenesis
- Cardiac regeneration
- Endothelial function
- Myocardial contractility
- Nitroso-redox balance
- S-nitrosylation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Nitric Oxide Regulation of Cardiovascular Physiology and Pathophysiology. / Dulce, Raul A.; Kulandavelu, Shathiyah; Schulman, Ivonne H; Fritsch, Julia; Hare, Joshua.
Nitric Oxide: Biology and Pathobiology: Third Edition. Elsevier Inc., 2017. p. 313-338.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Nitric Oxide Regulation of Cardiovascular Physiology and Pathophysiology
AU - Dulce, Raul A.
AU - Kulandavelu, Shathiyah
AU - Schulman, Ivonne H
AU - Fritsch, Julia
AU - Hare, Joshua
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The nitric oxide (NO) signaling pathway participates in regulating numerous facets of cardiovascular function, including myocardial contractility, ventricular relaxation, mitochondrial respiration, and endothelial function. As such, this pathway contributes to numerous facets of cardiovascular pathophysiology. NO plays a main role in both regulating and responding to the redox state of the cell (nitroso-redox balance), which targets calcium handling, contractile mechanisms, vasoactive mechanisms, as well as stem cell aspects involved in cardiac regeneration. Thus, the interaction between NO and reactive oxygen species (ROS), the nitroso-redox signaling pathway, is critically important in cardiac physiology and pathophysiology and a fundamental therapeutic target. This chapter will address the cardiovascular implications of the biological balance between NO and ROS as they relate to cardiac physiology and the pathophysiology of heart disease and offer insights for the development of new therapeutic strategies.
AB - The nitric oxide (NO) signaling pathway participates in regulating numerous facets of cardiovascular function, including myocardial contractility, ventricular relaxation, mitochondrial respiration, and endothelial function. As such, this pathway contributes to numerous facets of cardiovascular pathophysiology. NO plays a main role in both regulating and responding to the redox state of the cell (nitroso-redox balance), which targets calcium handling, contractile mechanisms, vasoactive mechanisms, as well as stem cell aspects involved in cardiac regeneration. Thus, the interaction between NO and reactive oxygen species (ROS), the nitroso-redox signaling pathway, is critically important in cardiac physiology and pathophysiology and a fundamental therapeutic target. This chapter will address the cardiovascular implications of the biological balance between NO and ROS as they relate to cardiac physiology and the pathophysiology of heart disease and offer insights for the development of new therapeutic strategies.
KW - Angiogenesis
KW - Cardiac regeneration
KW - Endothelial function
KW - Myocardial contractility
KW - Nitroso-redox balance
KW - S-nitrosylation
UR - http://www.scopus.com/inward/record.url?scp=85032155648&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032155648&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-804273-1.00024-7
DO - 10.1016/B978-0-12-804273-1.00024-7
M3 - Chapter
AN - SCOPUS:85032155648
SN - 9780128042731
SP - 313
EP - 338
BT - Nitric Oxide
PB - Elsevier Inc.
ER -