Nitric oxide (NO) synthase inhibitors abolish cocaine-induced toxicity in mice

Yossef Itzhak

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Repeated administration of cocaine (45 mg/kg/day) for 7 days to Swiss-Webster mice resulted in a progressive increase in the convulsive response to cocaine and augmentation in lethality rate. Pretreatment with the nitric oxide (NO) synthase inhibitors, l-name (100 mg/kg/day) or NO-Arg (25 mg/kg/day), prior to cocaine administration completely abolished the sensitization to the convulsive and lethal responses to cocaine. These findings suggest a role for NO in cocaine-induced toxicity.

Original languageEnglish (US)
Pages (from-to)1069-1070
Number of pages2
JournalNeuropharmacology
Volume32
Issue number10
DOIs
StatePublished - Oct 1993

Keywords

  • cocaine
  • convulsions
  • nitric oxide
  • sensitization

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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