Nitric oxide donors, sodium nitroprusside and S-nitroso-N- acetylpenicillamine, stimulate myoblast proliferation in vitro

J. A. Ulibarri, P. E. Mozdziak, E. Schultz, C. Cook, Thomas Best

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Nitric oxide (NO) is an inter- and intracellular messenger involved in a variety of physiologic and pathophysiologic conditions. The effect of two NO donors, sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) and their effect on myoblast proliferation was examined. Both donors stimulated an increase in myoblast cell number over a range (1-10 μM) of donor concentrations. However, 50 μM SNAP inhibited myoblast proliferation. Cell numbers from cultures treated with degraded 10 μM SNAP were equivalent to the control. Therefore, it appears NO can stimulate as well as inhibit myoblast proliferation.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalIn Vitro Cellular and Developmental Biology - Animal
Volume35
Issue number4
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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S-Nitroso-N-Acetylpenicillamine
Nitric Oxide Donors
Myoblasts
Nitroprusside
Nitric Oxide
Cell Count
Cell Culture Techniques
In Vitro Techniques

Keywords

  • Mitogenesis
  • Muscle
  • Turkey

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Nitric oxide donors, sodium nitroprusside and S-nitroso-N- acetylpenicillamine, stimulate myoblast proliferation in vitro. / Ulibarri, J. A.; Mozdziak, P. E.; Schultz, E.; Cook, C.; Best, Thomas.

In: In Vitro Cellular and Developmental Biology - Animal, Vol. 35, No. 4, 01.01.1999, p. 215-218.

Research output: Contribution to journalArticle

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