Nitric oxide donors, sodium nitroprusside and S-nitroso-N- acetylpenicillamine, stimulate myoblast proliferation in vitro

J. A. Ulibarri, P. E. Mozdziak, E. Schultz, C. Cook, T. M. Best

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Nitric oxide (NO) is an inter- and intracellular messenger involved in a variety of physiologic and pathophysiologic conditions. The effect of two NO donors, sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) and their effect on myoblast proliferation was examined. Both donors stimulated an increase in myoblast cell number over a range (1-10 μM) of donor concentrations. However, 50 μM SNAP inhibited myoblast proliferation. Cell numbers from cultures treated with degraded 10 μM SNAP were equivalent to the control. Therefore, it appears NO can stimulate as well as inhibit myoblast proliferation.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalIn Vitro Cellular and Developmental Biology - Animal
Volume35
Issue number4
DOIs
StatePublished - Apr 1999
Externally publishedYes

Keywords

  • Mitogenesis
  • Muscle
  • Turkey

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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