Nitric oxide - Angiotensin II axis in renal and cardiovascular injury

Ahmed Adam, Leopoldo Raij

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The knowledge and the information about Renin Angiotensin System and Arginine-Nitric Oxide pathway helped us in understanding more about cardiac, vascular and renal systems, their function, the physiology, and pathophysiology of different diseases that may affect them. The existence of a Nitric Oxide/Angiotensin II axis, brought modification to our ways of thinking with new and more pathophysiological approaches to the treatment of hypertension and end-organ disease. There appears to be a link between hypertension, salt sensitivity, endothelial function and NO-AngII axis on one side and end organ damage on the other side. Anti-hypertensive agents that can restore endothelial function beside their antihypertensive effect, may be better in preventing or at least slowing end-organ damage.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalJournal of Nephrology
Issue number3
StatePublished - May 1 2000


  • Angiotensin II
  • Cardio-vascular
  • Hypertension
  • Kidney
  • Nitric oxide

ASJC Scopus subject areas

  • Nephrology


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