Nitric oxide and cardiovascular and renal effects

Leopoldo Raij

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Nitric oxide (NO) has multiple protective effects for regulating the cardiovascular and renal systems. The major functions include endothelium-dependent relaxation, anti-inflammatory effects, as well as antihypertrophic and antithrombotic activities. Many of the activities mediated by NO are systematically antagonized by angiotensin-II (Ang II), a vasconstrictor peptide. Studies described in the review below have demonstrated that the balance between NO and Ang II activities rather than the absolute concentration of each molecule determines their effects on the physiology and pathophysiology of the cardiovascular and renal systems. NO donors have been used for years as therapeutic agents for a range of cardiovascular conditions including angina, myocardial infarction and for the reduction of arterial stiffness. An understanding of the mechanisms underlying the effects of these medications will enable the development of novel therapies to balance the effects of NO in the cardiovascular system.

Original languageEnglish (US)
Pages (from-to)S21-S26
JournalOsteoarthritis and Cartilage
Issue numberSUPPL. 2
StatePublished - Jun 1 2008


  • angiotensin II
  • atherosclerosis
  • hypertension
  • kidney
  • Nitric oxide
  • NO donors

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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