Nilotinib 300mg BID as frontline treatment of CML: Prospective analysis of the Xpert BCR-ABL Monitor system and significance of 3-month molecular response

Michael E. O'Dwyer, Ronan T Swords, Arnon Nagler, Mary Frances McMullin, Philipp D. le Coutre, Stephen E. Langabeer, Alberto Alvarez-Iglesias, Hongxin Fan, Richard C. Woodman, Francis J. Giles, Eibhlin Conneally

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Sixty patients with early chronic phase CML (ECPCML) received Nilotinib on a phase II study which included a comparison of the Xpert BCR-ABL Monitor™ PCR system with standardized (IS) BCR-ABL1 real-time quantitative PCR (RQ-PCR). 88% patients achieved MMR with 45% achieving MR4.5. At 3 months BCR-ABL1/ABL1 IS >1% and <10% was associated with a lower likelihood of subsequent MR4.5 compared to patients with lower levels (p= 0.018). No significant difference was observed between methodologies in identifying MMR. Nilotinib induces high molecular response rates in ECPCML and the Xpert BCR-ABL Monitor™ system merits further investigation in this setting.

Original languageEnglish
Pages (from-to)310-315
Number of pages6
JournalLeukemia Research
Volume38
Issue number3
DOIs
StatePublished - Mar 1 2014

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Real-Time Polymerase Chain Reaction
Therapeutics
Polymerase Chain Reaction
4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide

Keywords

  • CML BCR-ABL
  • Minimal residual disease
  • Molecular diagnostics
  • Nilotinib

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Nilotinib 300mg BID as frontline treatment of CML : Prospective analysis of the Xpert BCR-ABL Monitor system and significance of 3-month molecular response. / O'Dwyer, Michael E.; Swords, Ronan T; Nagler, Arnon; McMullin, Mary Frances; le Coutre, Philipp D.; Langabeer, Stephen E.; Alvarez-Iglesias, Alberto; Fan, Hongxin; Woodman, Richard C.; Giles, Francis J.; Conneally, Eibhlin.

In: Leukemia Research, Vol. 38, No. 3, 01.03.2014, p. 310-315.

Research output: Contribution to journalArticle

O'Dwyer, ME, Swords, RT, Nagler, A, McMullin, MF, le Coutre, PD, Langabeer, SE, Alvarez-Iglesias, A, Fan, H, Woodman, RC, Giles, FJ & Conneally, E 2014, 'Nilotinib 300mg BID as frontline treatment of CML: Prospective analysis of the Xpert BCR-ABL Monitor system and significance of 3-month molecular response', Leukemia Research, vol. 38, no. 3, pp. 310-315. https://doi.org/10.1016/j.leukres.2013.11.016
O'Dwyer, Michael E. ; Swords, Ronan T ; Nagler, Arnon ; McMullin, Mary Frances ; le Coutre, Philipp D. ; Langabeer, Stephen E. ; Alvarez-Iglesias, Alberto ; Fan, Hongxin ; Woodman, Richard C. ; Giles, Francis J. ; Conneally, Eibhlin. / Nilotinib 300mg BID as frontline treatment of CML : Prospective analysis of the Xpert BCR-ABL Monitor system and significance of 3-month molecular response. In: Leukemia Research. 2014 ; Vol. 38, No. 3. pp. 310-315.
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