NIH roundtable on emergency trauma research

Charles B. Cairns, Ronald V. Maier, Opeolu Adeoye, Darryl Baptiste, William G. Barsan, Lorne Blackbourne, Randall Burd, Christopher Carpenter, David Chang, William Cioffi, Edward Cornwell, J. Michael Dean, Carmel Dyer, David Jaffe, Geoff Manley, William J. Meurer, Robert Neumar, Robert Silbergleit, Molly Stevens, Michael WangDebra Weiner, David Wright, Robin Conwit, Billy Dunn, Basel Eldadah, Debra Egan, Rosemarie Filart, Giovanna Guerrero, Dallas Hack, Michael Handigan, David Heppel, Richard Hunt, Ramona Hicks, Scott Janis, Mary Kerr, Naomi Kleitman, Jeffrey Kopp, Walter J. Koroshetz, Jukka Korpela, Ryan Mutter, Carol Nicholson, Angela Martinelli, James Panagis, Jane Scott, Scott Somers, George Sopko, Veronica Thurmond, Bob Zalutsky

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Study objective: The National Institutes of Health (NIH) formed an NIH Task Force on Research in Emergency Medicine to enhance NIH support for emergency care research. The NIH Trauma Research Roundtable was convened on June 22 to 23, 2009. The objectives of the roundtable are to identify key research questions essential to advancing the scientific underpinnings of emergency trauma care and to discuss the barriers and best means to advance research by exploring the role of trauma research networks and collaboration between NIH and the emergency trauma care community. Methods: Before the roundtable, the emergency care domains to be discussed were selected and experts in each of the fields were invited to participate in the roundtable. Domain experts were asked to identify research priorities and challenges and separate them into mechanistic, translational, and clinical categories. During and after the conference, the lists were circulated among the participants and revised to reach a consensus. Results: Emergency trauma care research is characterized by focus on the timing, sequence, and time sensitivity of disease processes and treatment effects. Rapidly identifying the phenotype of patients on the time spectrum of acuity and severity after injury and the mechanistic reasons for heterogeneity in outcome are important challenges in emergency trauma research. Other research priorities include the need to elucidate the timing, sequence, and duration of causal molecular and cellular events involved in time-critical injuries, and the development of treatments capable of halting or reversing them; the need for novel experimental models of acute injury; the need to assess the effect of development and aging on the postinjury response; and the need to understand why there are regional differences in outcomes after injury. Important barriers to emergency care research include a limited number of trained investigators and experienced mentors, limited research infrastructure and support, and regulatory hurdles. Conclusion: The science of emergency trauma care may be advanced by facilitating the following: (1) development of an acute injury template for clinical research; (2) developing emergency trauma clinical research networks; (3) integrating emergency trauma research into Clinical and Translational Science Awards; (4) developing emergency carespecific initiatives within the existing structure of NIH institutes and centers; (5) involving acute trauma and emergency specialists in grant review and research advisory processes; (6) supporting learn-phase or small, clinical trials; (7) performing research to address ethical and regulatory issues; and (8) training emergency care investigators with research training programs.

Original languageEnglish
Pages (from-to)538-550
Number of pages13
JournalAnnals of Emergency Medicine
Volume56
Issue number5
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

Fingerprint

National Institutes of Health (U.S.)
Emergencies
Wounds and Injuries
Research
Emergency Medical Services
Research Personnel
Mentors
Emergency Medicine
Organized Financing
Advisory Committees

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Cairns, C. B., Maier, R. V., Adeoye, O., Baptiste, D., Barsan, W. G., Blackbourne, L., ... Zalutsky, B. (2010). NIH roundtable on emergency trauma research. Annals of Emergency Medicine, 56(5), 538-550. https://doi.org/10.1016/j.annemergmed.2010.05.029

NIH roundtable on emergency trauma research. / Cairns, Charles B.; Maier, Ronald V.; Adeoye, Opeolu; Baptiste, Darryl; Barsan, William G.; Blackbourne, Lorne; Burd, Randall; Carpenter, Christopher; Chang, David; Cioffi, William; Cornwell, Edward; Dean, J. Michael; Dyer, Carmel; Jaffe, David; Manley, Geoff; Meurer, William J.; Neumar, Robert; Silbergleit, Robert; Stevens, Molly; Wang, Michael; Weiner, Debra; Wright, David; Conwit, Robin; Dunn, Billy; Eldadah, Basel; Egan, Debra; Filart, Rosemarie; Guerrero, Giovanna; Hack, Dallas; Handigan, Michael; Heppel, David; Hunt, Richard; Hicks, Ramona; Janis, Scott; Kerr, Mary; Kleitman, Naomi; Kopp, Jeffrey; Koroshetz, Walter J.; Korpela, Jukka; Mutter, Ryan; Nicholson, Carol; Martinelli, Angela; Panagis, James; Scott, Jane; Somers, Scott; Sopko, George; Thurmond, Veronica; Zalutsky, Bob.

In: Annals of Emergency Medicine, Vol. 56, No. 5, 01.11.2010, p. 538-550.

Research output: Contribution to journalArticle

Cairns, CB, Maier, RV, Adeoye, O, Baptiste, D, Barsan, WG, Blackbourne, L, Burd, R, Carpenter, C, Chang, D, Cioffi, W, Cornwell, E, Dean, JM, Dyer, C, Jaffe, D, Manley, G, Meurer, WJ, Neumar, R, Silbergleit, R, Stevens, M, Wang, M, Weiner, D, Wright, D, Conwit, R, Dunn, B, Eldadah, B, Egan, D, Filart, R, Guerrero, G, Hack, D, Handigan, M, Heppel, D, Hunt, R, Hicks, R, Janis, S, Kerr, M, Kleitman, N, Kopp, J, Koroshetz, WJ, Korpela, J, Mutter, R, Nicholson, C, Martinelli, A, Panagis, J, Scott, J, Somers, S, Sopko, G, Thurmond, V & Zalutsky, B 2010, 'NIH roundtable on emergency trauma research', Annals of Emergency Medicine, vol. 56, no. 5, pp. 538-550. https://doi.org/10.1016/j.annemergmed.2010.05.029
Cairns CB, Maier RV, Adeoye O, Baptiste D, Barsan WG, Blackbourne L et al. NIH roundtable on emergency trauma research. Annals of Emergency Medicine. 2010 Nov 1;56(5):538-550. https://doi.org/10.1016/j.annemergmed.2010.05.029
Cairns, Charles B. ; Maier, Ronald V. ; Adeoye, Opeolu ; Baptiste, Darryl ; Barsan, William G. ; Blackbourne, Lorne ; Burd, Randall ; Carpenter, Christopher ; Chang, David ; Cioffi, William ; Cornwell, Edward ; Dean, J. Michael ; Dyer, Carmel ; Jaffe, David ; Manley, Geoff ; Meurer, William J. ; Neumar, Robert ; Silbergleit, Robert ; Stevens, Molly ; Wang, Michael ; Weiner, Debra ; Wright, David ; Conwit, Robin ; Dunn, Billy ; Eldadah, Basel ; Egan, Debra ; Filart, Rosemarie ; Guerrero, Giovanna ; Hack, Dallas ; Handigan, Michael ; Heppel, David ; Hunt, Richard ; Hicks, Ramona ; Janis, Scott ; Kerr, Mary ; Kleitman, Naomi ; Kopp, Jeffrey ; Koroshetz, Walter J. ; Korpela, Jukka ; Mutter, Ryan ; Nicholson, Carol ; Martinelli, Angela ; Panagis, James ; Scott, Jane ; Somers, Scott ; Sopko, George ; Thurmond, Veronica ; Zalutsky, Bob. / NIH roundtable on emergency trauma research. In: Annals of Emergency Medicine. 2010 ; Vol. 56, No. 5. pp. 538-550.
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abstract = "Study objective: The National Institutes of Health (NIH) formed an NIH Task Force on Research in Emergency Medicine to enhance NIH support for emergency care research. The NIH Trauma Research Roundtable was convened on June 22 to 23, 2009. The objectives of the roundtable are to identify key research questions essential to advancing the scientific underpinnings of emergency trauma care and to discuss the barriers and best means to advance research by exploring the role of trauma research networks and collaboration between NIH and the emergency trauma care community. Methods: Before the roundtable, the emergency care domains to be discussed were selected and experts in each of the fields were invited to participate in the roundtable. Domain experts were asked to identify research priorities and challenges and separate them into mechanistic, translational, and clinical categories. During and after the conference, the lists were circulated among the participants and revised to reach a consensus. Results: Emergency trauma care research is characterized by focus on the timing, sequence, and time sensitivity of disease processes and treatment effects. Rapidly identifying the phenotype of patients on the time spectrum of acuity and severity after injury and the mechanistic reasons for heterogeneity in outcome are important challenges in emergency trauma research. Other research priorities include the need to elucidate the timing, sequence, and duration of causal molecular and cellular events involved in time-critical injuries, and the development of treatments capable of halting or reversing them; the need for novel experimental models of acute injury; the need to assess the effect of development and aging on the postinjury response; and the need to understand why there are regional differences in outcomes after injury. Important barriers to emergency care research include a limited number of trained investigators and experienced mentors, limited research infrastructure and support, and regulatory hurdles. Conclusion: The science of emergency trauma care may be advanced by facilitating the following: (1) development of an acute injury template for clinical research; (2) developing emergency trauma clinical research networks; (3) integrating emergency trauma research into Clinical and Translational Science Awards; (4) developing emergency carespecific initiatives within the existing structure of NIH institutes and centers; (5) involving acute trauma and emergency specialists in grant review and research advisory processes; (6) supporting learn-phase or small, clinical trials; (7) performing research to address ethical and regulatory issues; and (8) training emergency care investigators with research training programs.",
author = "Cairns, {Charles B.} and Maier, {Ronald V.} and Opeolu Adeoye and Darryl Baptiste and Barsan, {William G.} and Lorne Blackbourne and Randall Burd and Christopher Carpenter and David Chang and William Cioffi and Edward Cornwell and Dean, {J. Michael} and Carmel Dyer and David Jaffe and Geoff Manley and Meurer, {William J.} and Robert Neumar and Robert Silbergleit and Molly Stevens and Michael Wang and Debra Weiner and David Wright and Robin Conwit and Billy Dunn and Basel Eldadah and Debra Egan and Rosemarie Filart and Giovanna Guerrero and Dallas Hack and Michael Handigan and David Heppel and Richard Hunt and Ramona Hicks and Scott Janis and Mary Kerr and Naomi Kleitman and Jeffrey Kopp and Koroshetz, {Walter J.} and Jukka Korpela and Ryan Mutter and Carol Nicholson and Angela Martinelli and James Panagis and Jane Scott and Scott Somers and George Sopko and Veronica Thurmond and Bob Zalutsky",
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T1 - NIH roundtable on emergency trauma research

AU - Cairns, Charles B.

AU - Maier, Ronald V.

AU - Adeoye, Opeolu

AU - Baptiste, Darryl

AU - Barsan, William G.

AU - Blackbourne, Lorne

AU - Burd, Randall

AU - Carpenter, Christopher

AU - Chang, David

AU - Cioffi, William

AU - Cornwell, Edward

AU - Dean, J. Michael

AU - Dyer, Carmel

AU - Jaffe, David

AU - Manley, Geoff

AU - Meurer, William J.

AU - Neumar, Robert

AU - Silbergleit, Robert

AU - Stevens, Molly

AU - Wang, Michael

AU - Weiner, Debra

AU - Wright, David

AU - Conwit, Robin

AU - Dunn, Billy

AU - Eldadah, Basel

AU - Egan, Debra

AU - Filart, Rosemarie

AU - Guerrero, Giovanna

AU - Hack, Dallas

AU - Handigan, Michael

AU - Heppel, David

AU - Hunt, Richard

AU - Hicks, Ramona

AU - Janis, Scott

AU - Kerr, Mary

AU - Kleitman, Naomi

AU - Kopp, Jeffrey

AU - Koroshetz, Walter J.

AU - Korpela, Jukka

AU - Mutter, Ryan

AU - Nicholson, Carol

AU - Martinelli, Angela

AU - Panagis, James

AU - Scott, Jane

AU - Somers, Scott

AU - Sopko, George

AU - Thurmond, Veronica

AU - Zalutsky, Bob

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Study objective: The National Institutes of Health (NIH) formed an NIH Task Force on Research in Emergency Medicine to enhance NIH support for emergency care research. The NIH Trauma Research Roundtable was convened on June 22 to 23, 2009. The objectives of the roundtable are to identify key research questions essential to advancing the scientific underpinnings of emergency trauma care and to discuss the barriers and best means to advance research by exploring the role of trauma research networks and collaboration between NIH and the emergency trauma care community. Methods: Before the roundtable, the emergency care domains to be discussed were selected and experts in each of the fields were invited to participate in the roundtable. Domain experts were asked to identify research priorities and challenges and separate them into mechanistic, translational, and clinical categories. During and after the conference, the lists were circulated among the participants and revised to reach a consensus. Results: Emergency trauma care research is characterized by focus on the timing, sequence, and time sensitivity of disease processes and treatment effects. Rapidly identifying the phenotype of patients on the time spectrum of acuity and severity after injury and the mechanistic reasons for heterogeneity in outcome are important challenges in emergency trauma research. Other research priorities include the need to elucidate the timing, sequence, and duration of causal molecular and cellular events involved in time-critical injuries, and the development of treatments capable of halting or reversing them; the need for novel experimental models of acute injury; the need to assess the effect of development and aging on the postinjury response; and the need to understand why there are regional differences in outcomes after injury. Important barriers to emergency care research include a limited number of trained investigators and experienced mentors, limited research infrastructure and support, and regulatory hurdles. Conclusion: The science of emergency trauma care may be advanced by facilitating the following: (1) development of an acute injury template for clinical research; (2) developing emergency trauma clinical research networks; (3) integrating emergency trauma research into Clinical and Translational Science Awards; (4) developing emergency carespecific initiatives within the existing structure of NIH institutes and centers; (5) involving acute trauma and emergency specialists in grant review and research advisory processes; (6) supporting learn-phase or small, clinical trials; (7) performing research to address ethical and regulatory issues; and (8) training emergency care investigators with research training programs.

AB - Study objective: The National Institutes of Health (NIH) formed an NIH Task Force on Research in Emergency Medicine to enhance NIH support for emergency care research. The NIH Trauma Research Roundtable was convened on June 22 to 23, 2009. The objectives of the roundtable are to identify key research questions essential to advancing the scientific underpinnings of emergency trauma care and to discuss the barriers and best means to advance research by exploring the role of trauma research networks and collaboration between NIH and the emergency trauma care community. Methods: Before the roundtable, the emergency care domains to be discussed were selected and experts in each of the fields were invited to participate in the roundtable. Domain experts were asked to identify research priorities and challenges and separate them into mechanistic, translational, and clinical categories. During and after the conference, the lists were circulated among the participants and revised to reach a consensus. Results: Emergency trauma care research is characterized by focus on the timing, sequence, and time sensitivity of disease processes and treatment effects. Rapidly identifying the phenotype of patients on the time spectrum of acuity and severity after injury and the mechanistic reasons for heterogeneity in outcome are important challenges in emergency trauma research. Other research priorities include the need to elucidate the timing, sequence, and duration of causal molecular and cellular events involved in time-critical injuries, and the development of treatments capable of halting or reversing them; the need for novel experimental models of acute injury; the need to assess the effect of development and aging on the postinjury response; and the need to understand why there are regional differences in outcomes after injury. Important barriers to emergency care research include a limited number of trained investigators and experienced mentors, limited research infrastructure and support, and regulatory hurdles. Conclusion: The science of emergency trauma care may be advanced by facilitating the following: (1) development of an acute injury template for clinical research; (2) developing emergency trauma clinical research networks; (3) integrating emergency trauma research into Clinical and Translational Science Awards; (4) developing emergency carespecific initiatives within the existing structure of NIH institutes and centers; (5) involving acute trauma and emergency specialists in grant review and research advisory processes; (6) supporting learn-phase or small, clinical trials; (7) performing research to address ethical and regulatory issues; and (8) training emergency care investigators with research training programs.

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