Nicotine receptors in the mammalian brain

Charles W Luetje, Jim Patrick, Philippe Séguéla

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Nicotine is a drug of abuse that presumably exerts its psychoactive effect through its interactions with nicotine binding sites in the central nervous system. Among its potential sites of action are the neuronal nicotinic acetylcholine receptors and the neuronal αbungarotoxin binding sites. In this review we focus on the neuronal nicotinic acetylcholine receptors, their diversity, distribution, and functions as nicotine receptors or as mediators of synaptic transmission in the mammalian brain. We find that the complexity characteristic of the gene family encoding the subunits of these receptors is reflected both in the pattern of expression of the genes and in the pharmacological diver-sity of the expressed receptors.

Original languageEnglish
Pages (from-to)2753-2760
Number of pages8
JournalFASEB Journal
Volume4
Issue number10
StatePublished - Dec 1 1990
Externally publishedYes

Fingerprint

nicotine
Nicotine
Brain
cholinergic receptors
Nicotinic Receptors
brain
receptors
binding sites
Genes
Binding Sites
drug abuse
synaptic transmission
Neurology
Street Drugs
Synaptic Transmission
Action Potentials
central nervous system
Central Nervous System
Pharmacology
Gene Expression

Keywords

  • α-bungarotoxin binding
  • Cholinergic
  • Distribution
  • Function
  • Nicotinic receptor

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Luetje, C. W., Patrick, J., & Séguéla, P. (1990). Nicotine receptors in the mammalian brain. FASEB Journal, 4(10), 2753-2760.

Nicotine receptors in the mammalian brain. / Luetje, Charles W; Patrick, Jim; Séguéla, Philippe.

In: FASEB Journal, Vol. 4, No. 10, 01.12.1990, p. 2753-2760.

Research output: Contribution to journalArticle

Luetje, CW, Patrick, J & Séguéla, P 1990, 'Nicotine receptors in the mammalian brain', FASEB Journal, vol. 4, no. 10, pp. 2753-2760.
Luetje CW, Patrick J, Séguéla P. Nicotine receptors in the mammalian brain. FASEB Journal. 1990 Dec 1;4(10):2753-2760.
Luetje, Charles W ; Patrick, Jim ; Séguéla, Philippe. / Nicotine receptors in the mammalian brain. In: FASEB Journal. 1990 ; Vol. 4, No. 10. pp. 2753-2760.
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