Smoking commonly is initiated during adolescence: thus, it is important to understand the consequences of early exposure to nicotine. Most studies have focused on male adults; however, in the past 15 years or so, there has been more attention paid to adolescence. More recently, studies have begun to include females. Preclinical laboratory studies show that male adolescents appear to be particularly susceptible to the effects of nicotine and that often the effects are different from adults and from females. Nicotine is more potent as a reward and a stimulant in adolescent males than in females or adults, and the long-term effects are more pronounced than in the other groups. A greater understanding of the differences between adult and adolescent drug responses will aid in the development of appropriate age- and sex-specific treatments for substance abuse.
|Original language||English (US)|
|Title of host publication||Neuroscience of Nicotine|
|Subtitle of host publication||Mechanisms and Treatment|
|Number of pages||7|
|State||Published - Jan 1 2019|
ASJC Scopus subject areas