Nicotine addiction causes unique detrimental effects on women's brains

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Nicotine addiction produces diverse physiological effects common to both men and women because of activation of the nicotinic acetylcholine receptors. In addition to these effects, nicotine reduces circulating estrogen (the female sex hormone) levels and leads to early onset of menopause in women. Nicotine's effect on estrogen metabolism has potential far-reaching consequences because endogenous circulating estrogen helps prevent cerebrovascular diseases in premenopausal women. In this article, the author presents a survey of literature showing that nicotine addiction causes unique deleterious effects in women's brains by inhibiting estrogen signaling, which makes the brain more susceptible to ischemic brain damage.

Original languageEnglish (US)
Pages (from-to)149-158
Number of pages10
JournalJournal of Addictive Diseases
Issue number2
StatePublished - Apr 2011


  • Aromatase
  • birth control pills
  • cerebral ischemia
  • estrogen
  • estrogen receptors
  • stroke

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Clinical Psychology


Dive into the research topics of 'Nicotine addiction causes unique detrimental effects on women's brains'. Together they form a unique fingerprint.

Cite this