Abstract
Nicotine addiction produces diverse physiological effects common to both men and women because of activation of the nicotinic acetylcholine receptors. In addition to these effects, nicotine reduces circulating estrogen (the female sex hormone) levels and leads to early onset of menopause in women. Nicotine's effect on estrogen metabolism has potential far-reaching consequences because endogenous circulating estrogen helps prevent cerebrovascular diseases in premenopausal women. In this article, the author presents a survey of literature showing that nicotine addiction causes unique deleterious effects in women's brains by inhibiting estrogen signaling, which makes the brain more susceptible to ischemic brain damage.
| Original language | English |
|---|---|
| Pages (from-to) | 149-158 |
| Number of pages | 10 |
| Journal | Journal of Addictive Diseases |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2011 |
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Keywords
- Aromatase
- birth control pills
- cerebral ischemia
- estrogen
- estrogen receptors
- stroke
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Nicotine addiction causes unique detrimental effects on women's brains. / Raval, Ami.
In: Journal of Addictive Diseases, Vol. 30, No. 2, 01.04.2011, p. 149-158.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nicotine addiction causes unique detrimental effects on women's brains
AU - Raval, Ami
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Nicotine addiction produces diverse physiological effects common to both men and women because of activation of the nicotinic acetylcholine receptors. In addition to these effects, nicotine reduces circulating estrogen (the female sex hormone) levels and leads to early onset of menopause in women. Nicotine's effect on estrogen metabolism has potential far-reaching consequences because endogenous circulating estrogen helps prevent cerebrovascular diseases in premenopausal women. In this article, the author presents a survey of literature showing that nicotine addiction causes unique deleterious effects in women's brains by inhibiting estrogen signaling, which makes the brain more susceptible to ischemic brain damage.
AB - Nicotine addiction produces diverse physiological effects common to both men and women because of activation of the nicotinic acetylcholine receptors. In addition to these effects, nicotine reduces circulating estrogen (the female sex hormone) levels and leads to early onset of menopause in women. Nicotine's effect on estrogen metabolism has potential far-reaching consequences because endogenous circulating estrogen helps prevent cerebrovascular diseases in premenopausal women. In this article, the author presents a survey of literature showing that nicotine addiction causes unique deleterious effects in women's brains by inhibiting estrogen signaling, which makes the brain more susceptible to ischemic brain damage.
KW - Aromatase
KW - birth control pills
KW - cerebral ischemia
KW - estrogen
KW - estrogen receptors
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=79957470750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957470750&partnerID=8YFLogxK
U2 - 10.1080/10550887.2011.554782
DO - 10.1080/10550887.2011.554782
M3 - Article
VL - 30
SP - 149
EP - 158
JO - Journal of Addictive Diseases
JF - Journal of Addictive Diseases
SN - 1055-0887
IS - 2
ER -