Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme

Rong Grace Zhai, Menico Rizzi, Silvia Garavaglia

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Nicotinamide/nicotinic acid mononucleotide adenylyltransferase (NMNAT) has long been known as the master enzyme in NAD biosynthesis in living organisms. A burst of investigations on NMNAT, going beyond enzymology, have paralleled increasing discoveries of key roles played by NAD homeostasis in a number or patho-physiological conditions. The availability of in-depth kinetics and structural enzymology analyses carried out on NMNATs from different organisms offer a powerful tool for uncovering fascinating evolutionary relationships. On the other hand, additional functions featuring NMNAT have emerged from investigations aimed at unraveling the molecular mechanisms responsible for complex biological phenomena such as neurodegeneration. NMNAT appears to be a multifunctional protein that sits both at the core of central metabolism and at a crossroads of multiple cellular processes. The resultant wealth of biochemical data has built a robust framework upon which design of NMNAT activators, inhibitors or enzyme variants of potential medical interest can be based.

Original languageEnglish (US)
Pages (from-to)2805-2818
Number of pages14
JournalCellular and Molecular Life Sciences
Volume66
Issue number17
DOIs
StatePublished - Sep 1 2009

Keywords

  • (5-8) NAD
  • Chimerical proteins
  • Crystal structures
  • Enzyme
  • Neuroprotection
  • Oligomeric assembly
  • Protein-protein interaction

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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