NF-κB signaling pathways regulated by CARMA family of scaffold proteins

Research output: Contribution to journalReview article

129 Scopus citations

Abstract

The NF-κB family of transcription factors plays a crucial role in cell activation, survival and proliferation. Its aberrant activity results in cancer, immunodeficiency or autoimmune disorders. Over the past two decades, tremendous progress has been made in our understanding of the signals that regulate NF-κB activation, especially how scaffold proteins link different receptors to the NF-κB-activating complex, the IκB kinase complex. The growing number of these scaffolds underscores the complexity of the signaling networks in different cell types. In this review, we discuss the role of scaffold molecules in signaling cascades induced by stimulation of antigen receptors, G-protein-coupled receptors and C-type Lectin receptors, resulting in NF-κB activation. Especially, we focus on the family of Caspase recruitment domain (CARD)-containing proteins known as CARMA and their function in activation of NF-κB, as well as the link of these scaffolds to the development of various neoplastic diseases through regulation of NF-κB.

Original languageEnglish (US)
Pages (from-to)55-70
Number of pages16
JournalCell Research
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

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Keywords

  • Bcl10
  • CARD9
  • CARMA1
  • CARMA2
  • CARMA3
  • IKK
  • NEMO
  • NF-κB

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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