Nexus formation in the myometrium during parturition and induced by estrogen

G. Dahl; W. Berger

doi:10.1016/0309-1651(78)90024-3

Nexus formation in the myometrium during parturition and induced by estrogen

G. Dahl, W. Berger

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The occurence of nexuses (gap junctions) in mouse uterine smooth muscle was found to depend on the hormonal state. As revealed by freeze-fracture electron microscopy, nexuses are virtually absent in virginal and pregnant mice. Abundant, large-sized nexuses were observed in the myometrium during parturition. Estrogen application to virginal mice also induced an increase in number and size of nexuses. Our observations indicate that a new formation of nexuses occurs in differentiated cells. New nexuses may be formed by the confluence of nexus subunits preexisting in the cell membrane or by newly biosynthesized components.

Original language	English (US)
Pages (from-to)	381-387
Number of pages	7
Journal	Cell Biology International Reports
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/0309-1651(78)90024-3
State	Published - Jul 1978
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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10.1016/0309-1651(78)90024-3

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title = "Nexus formation in the myometrium during parturition and induced by estrogen",

abstract = "The occurence of nexuses (gap junctions) in mouse uterine smooth muscle was found to depend on the hormonal state. As revealed by freeze-fracture electron microscopy, nexuses are virtually absent in virginal and pregnant mice. Abundant, large-sized nexuses were observed in the myometrium during parturition. Estrogen application to virginal mice also induced an increase in number and size of nexuses. Our observations indicate that a new formation of nexuses occurs in differentiated cells. New nexuses may be formed by the confluence of nexus subunits preexisting in the cell membrane or by newly biosynthesized components.",

author = "G. Dahl and W. Berger",

note = "Funding Information: ACKNOWLEDGEMENTS The Authors thank Mrs. I. Kiimmel and Mr. R. Weiss for excellent technical assistance and Mrs. M. Sinnwell for typing the manuscript. This work was supported by the Deutsche Forschungsge-meinschaft, Sonderforschungsbereich 38 {"}Membranfor-schung{"}. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1978",

month = jul,

doi = "10.1016/0309-1651(78)90024-3",

language = "English (US)",

volume = "2",

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journal = "Cell Biology International Reports",

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AU - Dahl, G.

AU - Berger, W.

N1 - Funding Information: ACKNOWLEDGEMENTS The Authors thank Mrs. I. Kiimmel and Mr. R. Weiss for excellent technical assistance and Mrs. M. Sinnwell for typing the manuscript. This work was supported by the Deutsche Forschungsge-meinschaft, Sonderforschungsbereich 38 "Membranfor-schung". Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1978/7

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N2 - The occurence of nexuses (gap junctions) in mouse uterine smooth muscle was found to depend on the hormonal state. As revealed by freeze-fracture electron microscopy, nexuses are virtually absent in virginal and pregnant mice. Abundant, large-sized nexuses were observed in the myometrium during parturition. Estrogen application to virginal mice also induced an increase in number and size of nexuses. Our observations indicate that a new formation of nexuses occurs in differentiated cells. New nexuses may be formed by the confluence of nexus subunits preexisting in the cell membrane or by newly biosynthesized components.

AB - The occurence of nexuses (gap junctions) in mouse uterine smooth muscle was found to depend on the hormonal state. As revealed by freeze-fracture electron microscopy, nexuses are virtually absent in virginal and pregnant mice. Abundant, large-sized nexuses were observed in the myometrium during parturition. Estrogen application to virginal mice also induced an increase in number and size of nexuses. Our observations indicate that a new formation of nexuses occurs in differentiated cells. New nexuses may be formed by the confluence of nexus subunits preexisting in the cell membrane or by newly biosynthesized components.

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Nexus formation in the myometrium during parturition and induced by estrogen

Abstract

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