Nexus formation in the myometrium during parturition and induced by estrogen

G. Dahl, W. Berger

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The occurence of nexuses (gap junctions) in mouse uterine smooth muscle was found to depend on the hormonal state. As revealed by freeze-fracture electron microscopy, nexuses are virtually absent in virginal and pregnant mice. Abundant, large-sized nexuses were observed in the myometrium during parturition. Estrogen application to virginal mice also induced an increase in number and size of nexuses. Our observations indicate that a new formation of nexuses occurs in differentiated cells. New nexuses may be formed by the confluence of nexus subunits preexisting in the cell membrane or by newly biosynthesized components.

Original languageEnglish (US)
Pages (from-to)381-387
Number of pages7
JournalCell Biology International Reports
Issue number4
StatePublished - Jul 1978
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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